2r6n: Difference between revisions
New page: left|200px<br /> <applet load="2r6n" size="450" color="white" frame="true" align="right" spinBox="true" caption="2r6n, resolution 1.950Å" /> '''Crystal structure ... |
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[[Image:2r6n. | [[Image:2r6n.jpg|left|200px]]<br /><applet load="2r6n" size="350" color="white" frame="true" align="right" spinBox="true" | ||
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caption="2r6n, resolution 1.950Å" /> | caption="2r6n, resolution 1.950Å" /> | ||
'''Crystal structure of a pyrrolopyrimidine inhibitor in complex with human Cathepsin K'''<br /> | '''Crystal structure of a pyrrolopyrimidine inhibitor in complex with human Cathepsin K'''<br /> | ||
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==Overview== | ==Overview== | ||
Pyrrolopyrimidine, a novel scaffold, allows to adjust interactions within, the S3 subsite of cathepsin K. The core intermediate 10 facilitated the P3, optimization and identified highly potent and selective cathepsin K, inhibitors 11-20. | Pyrrolopyrimidine, a novel scaffold, allows to adjust interactions within, the S3 subsite of cathepsin K. The core intermediate 10 facilitated the P3, optimization and identified highly potent and selective cathepsin K, inhibitors 11-20. | ||
==About this Structure== | ==About this Structure== | ||
2R6N is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CKE as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Cathepsin_K Cathepsin K], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.38 3.4.22.38] Full crystallographic information is available from [http:// | 2R6N is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CKE:'>CKE</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Cathepsin_K Cathepsin K], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.38 3.4.22.38] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R6N OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: zymogen]] | [[Category: zymogen]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 12:24:21 2008'' | ||
