Subtilisin: Difference between revisions
New page: left|200px|thumb|Crystal Structure of Subtilisin [[2z2x]] {{STRUCTURE_2z2x| PDB=2z2x | SIZE=300| SCENE= |right|CAPTION=Subtilisin 2z2x }} Subtilisin is a seri... |
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[[Image:2z2x.png|left|200px|thumb|Crystal Structure of Subtilisin [[2z2x]]]] | [[Image:2z2x.png|left|200px|thumb|Crystal Structure of Subtilisin [[2z2x]]]] | ||
{{STRUCTURE_2z2x| PDB=2z2x | SIZE=300| SCENE= |right|CAPTION=Subtilisin [[2z2x]] }} | {{STRUCTURE_2z2x| PDB=2z2x | SIZE=300| SCENE=Subtilisin/Cv/1 |right|CAPTION=Subtilisin [[2z2x]] }} | ||
[[Subtilisin]] is a serine protease. It is widely used commercially in detergents. | [[Subtilisin]] is a serine protease. It is widely used commercially in detergents. | ||
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=== Native mature subtilisin === | === Native mature subtilisin === | ||
2z2x – TkSub - ''Thermococcus kodakarensis'' | [[2z2x]] – TkSub - ''Thermococcus kodakarensis''<br /> | ||
1sca, 1scb, 1sbc – BsSub - Bacillus subtilis (Subtilisin Carlsberg) | [[1sca]], [[1scb]], [[1sbc]] – BsSub - ''Bacillus subtilis'' (Subtilisin Carlsberg)<br /> | ||
1gns, 1sup, 1st2, 1st1, 1s01, 1sbt, 2sbt – BaSub - Bacillus amyloliquefaciens | [[1gns]], [[1sup]], [[1st2]], [[1st1]], [[1s01]], [[1sbt]], [[2sbt]] – BaSub - ''Bacillus amyloliquefaciens''<br /> | ||
1iav, 1gci, 1jea, 1st3 – BlSub - Bacillus lentus (Subtilisin Savinase) | [[1iav]], [[1gci]], [[1jea]], [[1st3]] – BlSub - ''Bacillus lentus'' (Subtilisin Savinase)<br /> | ||
1ea7, 3d43, 2ixt – spehricase – Sub from Bacillus sphaericus | [[1ea7]], [[3d43]], [[2ixt]] – spehricase – Sub from ''Bacillus sphaericus'' | ||
=== Mutant mature subtilisin === | === Mutant mature subtilisin === | ||
3f49, 3co0, 2zrq – TkSubb (mutant) | [[3f49]], [[3co0]], [[2zrq]] – TkSubb (mutant) <br /> | ||
1gnv, 1dui, 1sue, 1a2q, 1aqn, 1sua, 1au9, 1ak9, 1yja, 1yjb, 1yjc, 1sbh, 1sbi, 1sub, 1suc, 1sud, 1s02 – BaSub (mutant) | [[1gnv]], [[1dui]], [[1sue]], [[1a2q]], [[1aqn]], [[1sua]], [[1au9]], [[1ak9]], [[1yja]], [[1yjb]], [[1yjc]], [[1sbh]], [[1sbi]], [[1sub]], [[1suc]], [[1sud]], [[1s02]] – BaSub (mutant)<br /> | ||
1ndu, 1q5p, 1c9j, 1c9m, 1c9n – BlSub (mutant) | [[1ndu]], [[1q5p]], [[1c9j]], [[1c9m]], [[1c9n]] – BlSub (mutant) | ||
=== Native unautoprocessed subtilisin (pro-Sub) === | === Native unautoprocessed subtilisin (pro-Sub) === | ||
2z2z, 2e1p – pro-TkSub | [[2z2z]], [[2e1p]] – pro-TkSub | ||
=== Mutant unautoprocessed subtilisin === | === Mutant unautoprocessed subtilisin === | ||
2zwo, 2zwp – pro-TKSub | [[2zwo]], [[2zwp]] – pro-TKSub | ||
=== Mature subtilisin complexed with its propeptide === | === Mature subtilisin complexed with its propeptide === | ||
3cnq – BaSub | [[3cnq]] – BaSub<br /> | ||
1spb – BaSub (mutant) | [[1spb]] – BaSub (mutant)<br /> | ||
3a3n, 3a3o, 3a3p, 2z56, 2z57, 2z58, 2z2y, 2z30 – TkSub | [[3a3n]], [[3a3o]], [[3a3p]], [[2z56]], [[2z57]], [[2z58]], [[2z2y]], [[2z30]] – TkSub<br /> | ||
1scj – BsSub | [[1scj]] – BsSub | ||
=== Subtilisin complexed with polypeptide inhibitor === | === Subtilisin complexed with polypeptide inhibitor === | ||
1y1k, 1y33, 1y34, 1y3b, 1y3c, 1y3d, 1y3f, 1y48, 1y4a, 1y4d, 1tm3, 1tm4, | [[1y1k]], [[1y33]], [[1y34]], [[1y3b]], [[1y3c]], [[1y3d]], [[1y3f]], [[1y48]], [[1y4a]], [[1y4d]], [[1tm3]], [[1tm4]], | ||
1tm1, 1lw6 – BaSub+ chymotripsin inhibitor 2 | [[1tm1]], [[1lw6]] – BaSub+ chymotripsin inhibitor 2<br /> | ||
3sic, 5sic, 2sic – BaSub+Streptomyces inhibitor SSI | [[3sic]], [[5sic]], [[2sic]] – BaSub+Streptomyces inhibitor SSI<br /> | ||
1yu6 – BsSub+ovomucoid | [[1yu6]] – BsSub+ovomucoid <br /> | ||
1v5i – BaSubb+POIA1 peptide | [[1v5i]] – BaSubb+POIA1 peptide <br /> | ||
1tk2, 1ndq – BlSub+gramicidin S | [[1tk2]], [[1ndq]] – BlSub+gramicidin S <br /> | ||
1r0r – BsSub+ovomucoid | [[1r0r]] – BsSub+ovomucoid<br /> | ||
1oyv – BsSub+tomato inhibitor II | [[1oyv]] – BsSub+tomato inhibitor II<br /> | ||
1sbn, 1sib, 2sec, 1sni, 1sce – BsSub+Elgin C | [[1sbn]], [[1sib]], [[2sec]], [[1sni]], [[1sce]] – BsSub+Elgin C<br /> | ||
1mee - BpSub+Elgin C – Bacillus pumilus | [[1mee]] - BpSub+Elgin C – ''Bacillus pumilus'' | ||
=== Subtilisin complexed with inhibitor === | === Subtilisin complexed with inhibitor === | ||
3bgo – BaSub+azide | [[3bgo]] – BaSub+azide <br /> | ||
1c3l – BsSub+Xe | [[1c3l]] – BsSub+Xe<br /> | ||
1be8 – BsSub+cinnamoyl | [[1be8]] – BsSub+cinnamoyl<br /> | ||
1be6 - BsSub+cinnamoyl+acetonitrile | [[1be6]] - BsSub+cinnamoyl+acetonitrile<br /> | ||
1bfk , | [[1bfk]], [[1scd]] – BsSub+acetonitrile<br /> | ||
1bfu, 1af4 – BsSub+dioxane | [[1bfu]], [[1af4]] – BsSub+dioxane<br /> | ||
1av7, 1avt, 3vsb, 1vsb – BsSub+boronic acid derivatives | [[1av7]], [[1avt]], [[3vsb]], [[1vsb]] – BsSub+boronic acid derivatives <br /> | ||
1scn – BsSub+carbamate derivative | [[1scn]] – BsSub+carbamate derivative <br /> | ||
1bh6 – Sub DY+benzyloxycarbonyl-ala-pro-phe-chloromethyl ketone | [[1bh6]] – Sub DY+benzyloxycarbonyl-ala-pro-phe-chloromethyl ketone – ''Bacillus licheniformis'' | ||
