1lph: Difference between revisions
New page: left|200px<br /> <applet load="1lph" size="450" color="white" frame="true" align="right" spinBox="true" caption="1lph, resolution 2.3Å" /> '''LYS(B28)PRO(B29)-HUM... |
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==About this Structure== | ==About this Structure== | ||
1LPH is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with ZN, CL and IPH as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1LPH OCA]]. | 1LPH is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with ZN, CL and IPH as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: 1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1LPH OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: insulin analogue]] | [[Category: insulin analogue]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:16:07 2007'' | ||
Revision as of 12:11, 30 October 2007
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LYS(B28)PRO(B29)-HUMAN INSULIN
OverviewOverview
BACKGROUND: LysB28ProB29-human insulin (Humalog), a fully potent insulin, analog in which the prolyl, lysyl sequence at the C-terminal end of the, B-chain is inverted, exhibits a decreased association of monomers to, dimers leading to rapid in vivo absorption. This provides important, benefits for the insulin-requiring diabetic. In spite of its monomeric, nature, LysB28ProB29-human insulin can exist as a discrete hexameric, structure in the presence of both zinc and phenol. Studies of the crystal, structure of LysB28ProB29-human insulin in a hexameric complex were, initiated to gain a molecular understanding of the effect of the sequence, inversion on the analog's self-association properties and, consequently, its in vivo efficacy. RESULTS: Under the conditions reported, ... [(full description)]
About this StructureAbout this Structure
1LPH is a [Protein complex] structure of sequences from [Homo sapiens] with ZN, CL and IPH as [ligands]. Structure known Active Site: 1. Full crystallographic information is available from [OCA].
ReferenceReference
Role of C-terminal B-chain residues in insulin assembly: the structure of hexameric LysB28ProB29-human insulin., Ciszak E, Beals JM, Frank BH, Baker JC, Carter ND, Smith GD, Structure. 1995 Jun 15;3(6):615-22. PMID:8590022
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