Pharmacokinetics: Difference between revisions
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The volume in which a drug is distributed after it has been injected intravenously and has equilibrated between the blood plasma and surrounding tissues. Although this value has no literal physiological meaning, V<sub>d</sub> is indicative of the extent of distribution of the drug. In general, highly plasma protein bound drugs will have a small V<sub>d</sub> while those drugs that are bound within tissues will have a large V<sub>d</sub>. As a rough approximation: | The volume in which a drug is distributed after it has been injected intravenously and has equilibrated between the blood plasma and surrounding tissues. Although this value has no literal physiological meaning, V<sub>d</sub> is indicative of the extent of distribution of the drug. In general, highly plasma protein bound drugs will have a small V<sub>d</sub> while those drugs that are bound within tissues will have a large V<sub>d</sub>. As a rough approximation: | ||
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! colspan="2" align="center"| V<sub>d</sub> Distribution Extent Comparisons | ! colspan="2" align="center"| V<sub>d</sub> Distribution Extent Comparisons | ||