Pharmacokinetics: Difference between revisions
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The volume in which a drug is distributed after it has been injected intravenously and has equilibrated between the blood plasma and surrounding tissues. Although this value has no literal physiological meaning, V<sub>d</sub> is indicative of the extent of distribution of the drug. In general, highly plasma protein bound drugs will have a small V<sub>d</sub> while those drugs that are bound within tissues will have a large V<sub>d</sub>. As a rough approximation: | The volume in which a drug is distributed after it has been injected intravenously and has equilibrated between the blood plasma and surrounding tissues. Although this value has no literal physiological meaning, V<sub>d</sub> is indicative of the extent of distribution of the drug. In general, highly plasma protein bound drugs will have a small V<sub>d</sub> while those drugs that are bound within tissues will have a large V<sub>d</sub>. As a rough approximation: | ||
{| class="wikitable" border="0px" width="100%" style="text-align:center" | |||
|- | |||
! colspan="2" align="center"| V<sub>d</sub> Distribution Extent Comparisons | |||
|- | |||
! V<sub>d</sub> (L) | |||
! Extent of Distribution | |||
|- | |||
! 5 | |||
! Only In Plasma | |||
|- | |||
! 5-20 | |||
! In Extracellular Fluids | |||
|- | |||
! 20-40 | |||
! In Total Body Fluids | |||
|- | |||
! >40 | |||
! In Deep tissues; Bound to Peripheral Tissues | |||
|} | |||
===Clearance (Cl)=== | ===Clearance (Cl)=== | ||