Captopril: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

David Canner, Alexander Berchansky

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 ===Pharmacokinetics===
-{| class="wikitable" border="1" width="50%" style="text-align:center"
+<table style="background: cellspacing="0px"  align="" cellpadding="0px" width="42%">
-|-
+<tr>
-!  colspan="8" align="center"| ACE-Inhibitor [[Pharmacokinetics]] Comparison at Equivalent Dosages <ref>PMID: 7867683</ref><ref>DOI: 10.1111/j.1365-2710.2005.00646.x</ref><ref>PMID: 16075412</ref><ref>PMID:7527101</ref>
+<td style="width:100%; vertical-align:top;border-width:0px; border-style:inset">
-|-
+<div style="height:100%; width: 100%">
-! Parameter
+{{:ACE Inhibitor Pharmacokinetics}}
-! [[Captopril]]
+</div>
-! [[Lisinopril]]
+</td>
-! [[Ramipril]]
+</tr>
-! [[Enalapril]]
+</table>
-! [[Benazepril]]
-! [[Perindopril]]
-! [[Trandolapril]]
-|-
-! [[Pharmacokinetics#Tmax|T<sub>max</sub>]] (hr)
-! .98
-! 6.5
-! .67
-! 1.06
-! .5
-! .75
-! .72
-|-
-! [[Pharmacokinetics#Cmax|C<sub>max</sub>]] (ng/ml)
-! 1210
-! 79
-! 16.4
-! 314
-! 149
-! 105
-! 1.68
-|-
-! [[Pharmacokinetics#Bioavailability_.28F.29|Bioavailability]] (%)
-! 72
-! 25
-! 28
-! 60
-! 97
-! 24
-! 10
-|-
-! [[Pharmacokinetics#Protein_Binding|Protein Binding]] (%)
-! 97
-! 0
-! 73
-! 20
-! 97
-! 20
-! 80
-|-
-! [[Pharmacokinetics#Half_Life_.28T1.2F2.29|T<sub>1/2</sub>]] (hr)
-! .56
-! 10.1
-! 1.93
-! 1.6
-! 10
-! .9
-! .68
-|-
-! [[Pharmacokinetics#Area_Under_the_Curve_.28AUC.29|AUC]] (ng/ml/hr)
-! 1673
-! 1016
-! 21.9
-! 450
-! 140
-! 182
-! 1.86
-|-
-! [[Pharmacokinetics#Inhibitory_Concentration_.28IC50.29|IC<sub>50</sub>]] (nM)
-! 1.1
-! 5.5
-! 5.0
-! 5.4
-! 1.7
-! 2.4
-! 2.5
-|-
-! Dosage (mg)
-! 10
-! 20
-! 5
-! 20
-! 10
-! 4
-! 2
-|-
-! Metabolism
-! Hepatic (CYP2D6)
-! None
-! Hepatic
-! Hepatic (CYP3A4)
-! Hepatic
-! Hepatic
-! Hepatic (CYP2D6 & CYP2C9)
-|}
 ==References==