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| <applet load="" size="480" color="" frame="true" spin="on" Scene ="Simvastatin/Just_simva/1" align="right" caption="Simvastatin, also known as Zocor"/> | | <applet load="" size="[450,380]" color="" frame="true" spin="on" Scene ="Simvastatin/Just_simva/1" align="right" caption="Simvastatin, also known as Zocor"/> |
| ===Better Known as: Zocor=== | | ===Better Known as: Zocor=== |
| * Marketed By: Merck & Co. Inc.<br /> | | * Marketed By: Merck & Co. Inc.<br /> |
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| ===Pharmacokinetics=== | | ===Pharmacokinetics=== |
| | | <table style="background: cellspacing="0px" align="" cellpadding="0px" width="42%"> |
| {| class="wikitable" border="1" width="48%" style="text-align:center"
| | <tr> |
| |-
| | <td style="width:100%; vertical-align:top;border-width:0px; border-style:inset"> |
| ! colspan="7" align="center"| Statin [[Pharmacokinetics]] at 10mg Dosage.<ref>PMID:11907637</ref><ref>PMID:15198967</ref><ref>PMID:12686673</ref><ref>PMID:18176327</ref><ref>PMID: 17452418</ref><ref>PMID:12895195</ref>
| | <div style="height:100%; width: 100%"> |
| |-
| | {{:Statin Pharmacokinetics}} |
| ! Parameter
| | </div> |
| ! [[Atorvastatin]] (Lipitor)
| | </td> |
| ! [[Fluvastatin]] (Lescol)
| | </tr> |
| ! [[Lovastatin]] (Mevacor)
| | </table> |
| ! [[Simvastatin]] (Zocor)
| |
| ! [[Rosuvastatin]] (Crestor)
| |
| ! [[Cerivastatin]] (Baycol)
| |
| |-
| |
| ! [[Pharmacokinetics#Tmax|T<sub>max</sub>]] (hr)
| |
| ! 2.5
| |
| ! 1
| |
| ! 3
| |
| ! 1.5
| |
| ! 4
| |
| ! 1.5
| |
| |-
| |
| ! [[Pharmacokinetics#Cmax|C<sub>max</sub>]] (ng/ml)
| |
| ! 27-66
| |
| ! 448
| |
| ! 10-20
| |
| ! 7.3
| |
| ! 4.34
| |
| ! 3.43
| |
| |-
| |
| ! [[Pharmacokinetics#Bioavailability_.28F.29|Bioavailability]] (%)
| |
| ! 12
| |
| ! 19-29
| |
| ! 5
| |
| ! 5
| |
| ! 20
| |
| ! 60
| |
| |-
| |
| ! [[Pharmacokinetics#Protein_Binding|Protein Binding]] (%)
| |
| ! 80-90
| |
| ! 99
| |
| ! 95
| |
| ! 95
| |
| ! 88
| |
| ! 99
| |
| |-
| |
| ! [[Pharmacokinetics#Half_Life_.28T1.2F2.29|T<sub>1/2</sub>]] (hr)
| |
| ! 15-30
| |
| ! 2
| |
| ! 3
| |
| ! 2.7
| |
| ! 19
| |
| ! 2.2
| |
| |-
| |
| ! [[Pharmacokinetics#Area_Under_the_Curve_.28AUC.29|AUC]] (ng/ml/hr)
| |
| ! 104
| |
| ! ~150
| |
| ! 33
| |
| ! 125
| |
| ! 48
| |
| ! 14.5
| |
| |-
| |
| ! [[Pharmacokinetics#Inhibitory_Concentration_.28IC50.29|IC<sub>50</sub>]] (nM)
| |
| ! 154
| |
| ! 198
| |
| ! 800-4200
| |
| ! 66
| |
| ! 320
| |
| ! 50-90
| |
| |-
| |
| ! Equivalent LDL Reduction Dosage (mg)
| |
| ! 10
| |
| ! --
| |
| ! 80
| |
| ! 20
| |
| ! 5
| |
| ! --
| |
| |-
| |
| ! Metabolism
| |
| ! Hepatic <br/>(CYP3A4)
| |
| ! Hepatic <br/>(CYP2C9)
| |
| ! Hepatic <br/>(CYP3A4)
| |
| ! Hepatic <br/>(CYP3A4)
| |
| ! Not <br/>Metabolized
| |
| ! Hepatic <br />(CYP2C8)
| |
| |}
| |
|
| |
|
| ===Effectiveness and Side Effects=== | | ===Effectiveness and Side Effects=== |