Donepezil: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

David Canner

@@ Line 13: / Line 13: @@
 ===Pharmacokinetics===
-{| class="wikitable" border="1" width="47%" style="text-align:center"
+<table style="background: cellspacing="0px"  align="" cellpadding="0px" width="50%">
-|-
+<tr>
-!  colspan="5" align="center"| Aceylcholinesterase Inhibitor [[Pharmacokinetics]]<ref>PMID:17113365</ref><ref>PMID: 19935404</ref><ref>PMID:7605915</ref><ref>PMID:1404819</ref><ref>doi:10.1053/cp.1999.v66.103404001</ref><ref>doi:10.1038/sj.clpt.6100242</ref><ref>PMID:12734391</ref><ref>PMID: 11741490</ref>
+<td style="width:100%; vertical-align:top;border-width:0px; border-style:inset">
-|-
+<div style="height:100%; width: 100%">
-! Parameter
+{{:Acetylcholinesterase Inhibitor Pharmacokinetics}}
-! [[Donepezil]]
+</div>
-! [[Tacrine]]
+</td>
-! [[Rivastigmine]]
+</tr>
-! [[Galantamine]]
+</table>
-|-
-! [[Pharmacokinetics#Tmax|T<sub>max</sub>]] (hr)
-! 3.6
-! 1.5
-! .3
-! 1.2
-|-
-! [[Pharmacokinetics#Cmax|C<sub>max</sub>]] (ng/ml)
-! 6.5
-! 15.7
-! 29.3
-! 42.6
-|-
-! [[Pharmacokinetics#Bioavailability_.28F.29|Bioavailability]] (%)
-! 100
-! 17
-! 36
-! 100
-|-
-! [[Pharmacokinetics#Protein_Binding|Protein Binding]] (%)
-! 96
-! 55
-! 40
-! 10
-|-
-! [[Pharmacokinetics#Half_Life_.28T1.2F2.29|T<sub>1/2</sub>]] (hr)
-! 70
-! 3
-! 5
-! 7.3
-|-
-! [[Pharmacokinetics#Area_Under_the_Curve_.28AUC.29|AUC]] (ng/ml/hr)
-! 380
-! 80.4
-! 191
-! 427
-|-
-! [[Pharmacokinetics#Inhibitory_Concentration_.28IC50.29|IC<sub>50</sub>]] (nM)
-! 6.7 <br/>(Rat)
-! 450 <br/>(Human)
-! 1535 <br/>(Human)
-! 1995 <br/>(Rat)
-|-
-! Dosage (mg)
-! 5
-! 160
-! 6
-! 8
-|-
-! Metabolism
-! Hepatic (CYP2D6 & CYP3A4) & Cholinesterase
-! Hepatic (CYP1A2) & Cholinesterase
-! Cholinesterase
-! Hepatic (CYP3A4 & CYP2D6) & Cholinesterase
-|}
 ===References===