Parvin: Difference between revisions
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===ILK binding=== | ===ILK binding=== | ||
<Structure load='3kmw' size='360' scene='Alpha-parvin/Ilk_parvin/1' frame='true' align='left' caption='Crystal structure of the kinase domain of ILK/C-terminal CH domain of alpha-parvin core complex ([[3kmw]])'/> | <Structure load='3kmw' size='360' scene='Alpha-parvin/Ilk_parvin/1' frame='true' align='left' caption='Crystal structure of the kinase domain of ILK/C-terminal CH domain of alpha-parvin core complex ([[3kmw]])'/> | ||
The <scene name='Alpha-parvin/Ilk_parvin/1'>scene on the left</scene> shows the complex of the kinase domain of integrin-linked kinase (ILK, red) bound to the C-terminal CH domain of alpha-parvin (blue). | The <scene name='Alpha-parvin/Ilk_parvin/1'>scene on the left</scene> shows the complex of the kinase domain of integrin-linked kinase (ILK, red) bound to the C-terminal CH domain of alpha-parvin (blue). One can also see the molecule of ATP (green) and the space-fill representation of the magnesium atom (white). When we | ||
turn the structure</scene> so that the N-terminal helix (now orange) of the CH domain of alpha-parvin is pointing up, we can see that unlike paxillin LD motifs, ILK kinase domain does not bind to the N-terminal region of the CH domain, but rather to the long loop between helices αC and αE. | |||
==References== | ==References== | ||
<references /> | <references /> | ||