2jc3: Difference between revisions
New page: left|200px<br /> <applet load="2jc3" size="450" color="white" frame="true" align="right" spinBox="true" caption="2jc3, resolution 2.30Å" /> '''STRUCTURE OF O-ACET... |
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==About this Structure== | ==About this Structure== | ||
2JC3 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium]] with PLP as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2JC3 OCA]]. | 2JC3 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium]] with PLP as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2JC3 OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: vitamin b6 dependent enzyme]] | [[Category: vitamin b6 dependent enzyme]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:14:03 2007'' | ||
Revision as of 12:09, 30 October 2007
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STRUCTURE OF O-ACETYLSERINE SULFHYDRYLASE B FROM SALMONELLA TYPHIMURIUM
OverviewOverview
O-Acetylserine sulfhydrylase is a pyridoxal 5'-phosphate-dependent enzyme, that catalyzes the final step in the cysteine biosynthetic pathway in, enteric bacteria and plants, the replacement of the beta-acetoxy group of, O-acetyl-l-serine by a thiol to give l-cysteine. Two isozymes are found in, Salmonella typhimurium, with the A-isozyme expressed under aerobic and the, B-isozyme expressed under anaerobic conditions. The structure of, O-acetylserine sulfhydrylase B has been solved to 2.3 A and exhibits, overall a fold very similar to that of the A-isozyme. The main difference, between the two isozymes is the more hydrophilic active site of the, B-isozyme with two ionizable residues, C280 and D281, replacing the, neutral residues S300 and P299, respectively, in the A-isozyme. D281 is, ... [(full description)]
About this StructureAbout this Structure
2JC3 is a [Single protein] structure of sequence from [Salmonella typhimurium] with PLP as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
Structure, Mechanism, and Conformational Dynamics of O-Acetylserine Sulfhydrylase from Salmonella typhimurium: Comparison of A and B Isozymes., Chattopadhyay A, Meier M, Ivaninskii S, Burkhard P, Speroni F, Campanini B, Bettati S, Mozzarelli A, Rabeh WM, Li L, Cook PF, Biochemistry. 2007 Jul 17;46(28):8315-30. Epub 2007 Jun 21. PMID:17583914
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