Colicin A: Difference between revisions
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Colicin A is a type of [[Colicin]], a bacteriocin made by | Colicin A is a type of [[Colicin]], a bacteriocin made by <i>E. Coli</i> which acts against other nearby <i>E. Coli</i> to kill them by forming a pore in the membrane, leading to depolarisation of the membrane which kills the cell. | ||
==Synthesis and release== | ==Synthesis and release== | ||
==Mechanism of uptake== | ==Mechanism of uptake== | ||
Colicin A binds to the BtuB Vitamin B12 outer membrane receptor of the target cell, and uses the [[Tol]] system to translocate across the membrane, specifically TolQRAB, alongside the OmpF protein. | |||
==Killing Activities== | ==Killing Activities== | ||
Colicin A is a pore-forming colicin, which means that its cytotoxic domain inserts into the membrane of the target cell, resulting in the depolarisation of the cell membrane. <i>E. coli</i> uses the polarisation of its cell membrane to generate energy, so without this it is unable to generate energy, and the cell ultimately dies. | |||