Donepezil: Difference between revisions

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 * The following is a list of Pharmacokinetic Parameters. See: [[Pharmaceutical Drugs]] for more information
 ===Mechanism of Action===
-Aricept is a potent [[Acetylcholinesterase]] inhibitor. It binds along the active-site gorge, extending from the anionic subsite (W84) to the peripheral anionic site (w279). Interestingly, it does not directly interact with the catalytic triad or Oxyanion hole of AChE, but rather only interacts via aromatic stacking and solvent mediated interactions.
+Aricept is a potent [[Acetylcholinesterase]] inhibitor that binds the active site of <scene name='Donepezil/Ache/1'>AChE</scene>. It binds along the active-site gorge, extending from the anionic subsite near <scene name='Donepezil/Trp_84/1'>Trp 84</scene> to the peripheral anionic site near <scene name='Donepezil/Trp_279/1'>Trp 279</scene>. Interestingly, it does not directly interact with the catalytic triad or Oxyanion hole of AChE, but rather only interacts via aromatic stacking and solvent mediated interactions. It <scene name='Donepezil/Bound/1'>primarily interacts</scene> with Glu 199, His 440, Phe 330, Trp 84, Tyr 334, Tyr 121, Phe 331, Phe 288, Ser 286, Phe 290, Arg 289, Trp 279, & Leu 282 to tightly bind to AChE.
-<scene name='Donepezil/Ache/1'>TextToBeDisplayed</scene>
-<scene name='Donepezil/Bound/1'>TextToBeDisplayed</scene>
 ===Pharmacokinetics===
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