Human Cardiac Troponin C: Difference between revisions
No edit summary |
No edit summary |
||
| Line 26: | Line 26: | ||
[[Image:EGC-TnC2.jpg|300px|Figure 1: EGCg-TnC complex]] | [[Image:EGC-TnC2.jpg|300px|Figure 1: EGCg-TnC complex]] | ||
[[Image:Pocket surface.jpg|300px|Pocket with a surface representation]] | [[Image:Pocket surface.jpg|300px|Pocket with a surface representation]] | ||
[[Image:1dqa opening.png|300px|left|thumb| Human HMG-CoA Reductase Catalytic Domain, [[1dqa]]]] | |||
As said just before, EGCg makes contacts exclusively to hydrophobic residues that line the surface of TnC. Actually it binds near the surface of helix E, so near the N-terminus of TnC, with tetrahydropyran and benzenediol. The pyrogallol ring stays near the C-terminus of TnC, which explains the large chemical shift perturbations of some residues of the <scene name='Human_Cardiac_Troponin_C/Helix_h/1'>Helix H</scene>. | As said just before, EGCg makes contacts exclusively to hydrophobic residues that line the surface of TnC. Actually it binds near the surface of helix E, so near the N-terminus of TnC, with tetrahydropyran and benzenediol. The pyrogallol ring stays near the C-terminus of TnC, which explains the large chemical shift perturbations of some residues of the <scene name='Human_Cardiac_Troponin_C/Helix_h/1'>Helix H</scene>. | ||