Human Cardiac Troponin C: Difference between revisions
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[[2KDH]] is the Solution Structure of Human Cardiac Troponin C in complex with the Green Tea Polyphenol : (-)-epigallocatechin-3-gallate. It is a 1 chain structure of sequence from [http://fr.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. That is the PDB name for the solution structure of Human Cardiac Troponin C in complex with the green tea Polyphenol (-)-epigallocatechin-3-gallate. | [[2KDH]] is the Solution Structure of Human Cardiac Troponin C in complex with the Green Tea Polyphenol : (-)-epigallocatechin-3-gallate. It is a 1 chain structure of sequence from [http://fr.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. That is the PDB name for the solution structure of Human Cardiac Troponin C in complex with the green tea Polyphenol (-)-epigallocatechin-3-gallate. | ||
Troponin C is a protein which can bind with calcium. That’s a subunit from a 3 subunited protein which is called Troponin. This protein is found in muscles. | Troponin C is a protein which can bind with calcium. That’s a subunit from a 3 subunited protein which is called Troponin. This protein is found in muscles. | ||
For example, heart muscle contraction is regulated by Ca2+ binding of troponin C to the thin filament. In cardiovascular diseases, the myofilament response to Ca2+ is often altered. Compounds that rectify this perturbation are of considerable interest as therapeutics. Plant [http://en.wikipedia.org/wiki/Flavonoid flavonoids] have been found to provide protection against a variety of human illnesses such as cancers, infections, and heart diseases. (-)-Epigallocatechin gallate (EGCg), the prevalent flavonoid in green tea is one of those plant flavonoids. | For example, heart muscle contraction is regulated by Ca2+ binding of troponin C to the thin filament.<ref>PMID:19542563</ref> In cardiovascular diseases, the myofilament response to Ca2+ is often altered. Compounds that rectify this perturbation are of considerable interest as therapeutics. Plant [http://en.wikipedia.org/wiki/Flavonoid flavonoids] have been found to provide protection against a variety of human illnesses such as cancers, infections, and heart diseases. (-)-Epigallocatechin gallate (EGCg), the prevalent flavonoid in green tea is one of those plant flavonoids. | ||
== From the binding of Ca2+ with TnC to the muscular contraction == | == From the binding of Ca2+ with TnC to the muscular contraction == | ||