Chloride Intracellular Channel Protein 2: Difference between revisions
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''Two different forms of CLIC2 which differ by 18 residues: form A (blue) and form B (grey). | ''Two different forms of CLIC2 which differ by 18 residues: form A (blue) and form B (grey). | ||
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CLIC proteins are a new class of soluble and membrane-bound proteins that have been grouped together on the basis of their sequence similarity. The proteins were named CLIC because the first members of this family to be characterized formed intracellular chloride channels (Heiss & Poustka, 1997). They display broad tissue and cellular distribution. They have been implicated in kidney function, cell division, and bone resorption. (Brett A. Cromer and al, 2007 1) They differ from the other classes of chloride ion channels in primary structure and in the transmembrane regions of the tertiary structure. Since the first member of CLIC, p64 (CLIC5), was discovered in bovine kidney, several members of the CLIC family have been found in other tissues from many species, including NCC27 (CLIC1), CLIC2, CLIC3, mtCLIC (CLIC4), and parchorin (CLIC6). (X. Meng and al, 2009) With the exception of p64 and parchorin, these proteins contain a conserved region of approximately 240 residues. (Brett A. Cromer and al, 2007 2) | CLIC proteins are a new class of soluble and membrane-bound proteins that have been grouped together on the basis of their sequence similarity. The proteins were named CLIC because the first members of this family to be characterized formed intracellular chloride channels (Heiss & Poustka, 1997). They display broad tissue and cellular distribution. They have been implicated in kidney function, cell division, and bone resorption. (Brett A. Cromer and al, 2007 1) They differ from the other classes of chloride ion channels in primary structure and in the transmembrane regions of the tertiary structure. Since the first member of CLIC, p64 (CLIC5), was discovered in bovine kidney, several members of the CLIC family have been found in other tissues from many species, including NCC27 (CLIC1), CLIC2, CLIC3, mtCLIC (CLIC4), and parchorin (CLIC6). (X. Meng and al, 2009) With the exception of p64 and parchorin, these proteins contain a conserved region of approximately 240 residues. (Brett A. Cromer and al, 2007 2) | ||