Insulin-Degrading Enzyme: Difference between revisions
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== Introduction == | == Introduction == | ||
[[Insulin-Degrading Enzyme]] is a highly conserved 2*113 kDa homodimeric zinc metalloprotease. It belongs to the M16A family of metalloproteases within the ME clan. It hydrolyses insulin and several amyloidogenic peptides like amyloid-β (Aβ). | |||
Aβ is the main component of brain and of the amyloid islets found in Alzheimer’s disease. | Aβ is the main component of brain and of the amyloid islets found in Alzheimer’s disease. | ||
Insulin is a peptide associated with diabete. The gene encoding IDE is located on human chromosome 10q and is in a region linked to type 2 diabete and Alzheimer’s disease. | Insulin is a peptide associated with diabete. The gene encoding IDE is located on human chromosome 10q and is in a region linked to type 2 diabete and Alzheimer’s disease. | ||