1a80: Difference between revisions
New page: left|200px<br /> <applet load="1a80" size="450" color="white" frame="true" align="right" spinBox="true" caption="1a80, resolution 2.1Å" /> '''NATIVE 2,5-DIKETO-D-... |
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==About this Structure== | ==About this Structure== | ||
1A80 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Corynebacterium_sp. Corynebacterium sp.]] with NAP as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1A80 OCA]]. | 1A80 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Corynebacterium_sp. Corynebacterium sp.]] with NAP as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: CIC. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1A80 OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: oxidoreductase]] | [[Category: oxidoreductase]] | ||
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Revision as of 12:07, 30 October 2007
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NATIVE 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE A FROM CORYNBACTERIUM SP. COMPLEXED WITH NADPH
OverviewOverview
The three-dimensional structure of Corynebacterium 2, 5-diketo-D-gluconic, acid reductase A (2,5-DKGR A; EC 1.1.1.-), in complex with cofactor NADPH, has been solved by using x-ray crystallographic data to 2.1-A resolution., This enzyme catalyzes stereospecific reduction of 2,5-diketo-D-gluconate, (2,5-DKG) to 2-keto-L-gulonate. Thus the three-dimensional structure has, now been solved for a prokaryotic example of the aldo-keto reductase, superfamily. The details of the binding of the NADPH cofactor help to, explain why 2,5-DKGR exhibits lower binding affinity for cofactor than the, related human aldose reductase does. Furthermore, changes in the local, loop structure near the cofactor suggest that 2,5-DKGR will not exhibit, the biphasic cofactor binding characteristics observed in ... [(full description)]
About this StructureAbout this Structure
1A80 is a [Single protein] structure of sequence from [Corynebacterium sp.] with NAP as [ligand]. Structure known Active Site: CIC. Full crystallographic information is available from [OCA].
ReferenceReference
Crystal structure of 2,5-diketo-D-gluconic acid reductase A complexed with NADPH at 2.1-A resolution., Khurana S, Powers DB, Anderson S, Blaber M, Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6768-73. PMID:9618487
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