AZT-resistant HIV-1 reverse transcriptase: Difference between revisions
| Line 41: | Line 41: | ||
2. excision- removal of AZTTP from the viral DNA after it has been incorporated into the host genome | 2. excision- removal of AZTTP from the viral DNA after it has been incorporated into the host genome | ||
The excision mechanism has been shown to result from a set of mutations. [[Reverse transcriptase]] isolated from patients with AZT-resistant viruses do not typically have all of these mutations, however, combinations of the mutations give rise to high levels of resistance to AZT. | |||
==References== | ==References== | ||