AZT-resistant HIV-1 reverse transcriptase: Difference between revisions

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 '''Fingers Subdomain'''
-The nucleic-acid binding cleft is primarily formed by the p66 [[polymerase]] and RNase H subdomains.  The p51 thumb and connection subdomains form the floor of the binding cleft.  In this way, the binding cleft is positioned so that both the polymerase and the RNAse H active sites come in contact with the nucleic acid.
+The nucleic-acid binding cleft is primarily formed by the p66 polymerase and RNase H subdomains.  The p51 thumb and connection subdomains form the floor of the binding cleft.  In this way, the binding cleft is positioned so that both the polymerase and the RNAse H active sites come in contact with the nucleic acid.
+When polymerase activity begins, [[reverse transcriptase]] binds to the nucleic acid substrate.
 ==Inhibition of Reverse Transcriptase Activity==