AZT-resistant HIV-1 reverse transcriptase: Difference between revisions
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==Structure of Reverse Transcriptase== | ==Structure of Reverse Transcriptase== | ||
[[Reverse transcriptase]] is a heterodimer of two related <scene name='AZT-resistant_HIV-1_reverse_transcriptase/Subunits/1'>subunits</scene>: p66 and p51. These subunits consist of four sub-domains fingers, thumb, palm, and connection, although the positions of the sub-domains relative to each other is different for each subunit. | [[Reverse transcriptase]] is a heterodimer of two related <scene name='AZT-resistant_HIV-1_reverse_transcriptase/Subunits/1'>subunits</scene>: p66 and p51. These subunits consist of four sub-domains fingers, thumb, palm, and connection, although the positions of the sub-domains relative to each other is different for each subunit. The larger subunit, p66, contains the active sites for both enzymatic activities (DNA polymerase and RNase H), while the smaller subunit, p51, has a structural role. | ||
{{STRUCTURE_3klg | PDB=3klg | SCENE= }} | {{STRUCTURE_3klg | PDB=3klg | SCENE= }} | ||