Rosuvastatin: Difference between revisions
David Canner (talk | contribs) No edit summary |
David Canner (talk | contribs) No edit summary |
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! Equivalent LDL Reduction Dosage (mg) | |||
! 10 | |||
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! 80 | |||
! 20 | |||
! 5 | |||
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! Metabolism | ! Metabolism | ||
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===Effectiveness and Side Effects=== | ===Effectiveness and Side Effects=== | ||
====Effectiveness==== | ====Effectiveness==== | ||
<ref>PMID:20456733</ref> | Rosuvastatin has the greatest efficacy compared to other statins at the same dosage. At 5mg, patients experienced a 40% or greater reduction in LDL as compared to similar results for [[Atorvastatin]] at 20mg doses. <ref>PMID:20456733</ref> | ||
====Side Effects==== | ====Side Effects==== | ||
Although all of the statins are generally considered safe, rosuvastatin had a higher reported adverse event rate than other statin clinical trials. Typical adverse events include muscle weakness, headache dizziness and slightly increased creatinine kinase (CK) levels (an indication of kidney and smooth muscle damage), although these are common to all the statins (with the exception of elevated CK levels which only occurs in [[Atorvastatin]], [[Rosuvastatin]], and [[Simvastatin]])<ref>PMID:20456733</ref> | |||
===Interesting Facts=== | ===Interesting Facts=== | ||
* Rosuvastatin | * Rosuvastatin has made recent headlines as being nearly equivalent in efficacy to Lipitor, but also cuts the rate of heart attacks and strokes significantly. <ref>PMID:20026779</ref> | ||
* Unlike other statins, consuming grapefruit juice does not affect the PKs of rosuvastatin. <ref>PMID:9585793</ref> <ref>PMID: 11836106</ref> | |||
===The Jist=== | ===The Jist=== | ||
The statins work! They are generally viewed as very safe and have been proven effective over the past 15 years. | The statins work! They are generally viewed as very safe and have been proven effective over the past 15 years. | ||