Phospholipase A2: Difference between revisions
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[[1qll]], [[2q2j]] – PLA2 – Bothrops pirajai | [[1qll]], [[2q2j]] – PLA2 – ''Bothrops pirajai''<br /> | ||
[[2zp3]], [[2zp4]], [[2zp5]] – bPLA2 (mutant) – bovine | [[2zp3]], [[2zp4]], [[2zp5]] – bPLA2 (mutant) – bovine<br /> | ||
[[2qog]] – PLA2 – Crotalus durissus | [[2qog]] – PLA2 – ''Crotalus durissus''<br /> | ||
[[2ph4]] – PLA2 – Zhaoermia mangshanensis | [[2ph4]] – PLA2 – ''Zhaoermia mangshanensis''<br /> | ||
[[2h4c]], [[1q6v]] – IvPLA2 – Indian viper | [[2h4c]], [[1q6v]] – IvPLA2 – Indian viper<br /> | ||
[[2osn]], [[1fe5]], [[1dpy]] – kPLA2 – krait | [[2osn]], [[1fe5]], [[1dpy]] – kPLA2 – krait<br /> | ||
1g0z, 1g2x – kPLA2 (mutant) | [[1g0z]], [[1g2x]] – kPLA2 (mutant)<br /> | ||
2wg7, 2wg8 – rPLA2 – rice | [[2wg7]], [[2wg8]] – rPLA2 – rice<br /> | ||
1yxh – NsPLA2 – Naja sagittifera | [[1yxh]] – NsPLA2 – ''Naja sagittifera''<br /> | ||
1y6p – pPLA2 (mutant) – pig | [[1y6p]] – pPLA2 (mutant) – pig<br /> | ||
1sfv, 1sfw, 1pir, 1pis – pPLA2 - NMR | [[1sfv]], [[1sfw]], [[1pir]], [[1pis]] – pPLA2 - NMR<br /> | ||
1oz6 – PLA2 – Echis carinatus | [[1oz6]] – PLA2 – ''Echis carinatus''<br /> | ||
1it4, 1it5 – PLA2 – Stretomyces violaceoruber – NMR | [[1it4]], [[1it5]] – PLA2 – Stretomyces violaceoruber – NMR<br /> | ||
1mg6 – PLA2 – Agkistrodon acutus | [[1mg6]] – PLA2 – ''Agkistrodon acutus''<br /> | ||
1mc2 – PLA2 – Chinese moccasin | [[1mc2]] – PLA2 – Chinese moccasin<br /> | ||
1c74, 1kvw, 1kvx, 1kvy, 1ceh – bPLA2 (mutant) – bovine | [[1c74]], [[1kvw]], [[1kvx]], [[1kvy]], [[1ceh]] – bPLA2 (mutant) – bovine<br /> | ||
1une, 1mkt, 1irb - bPLA2 | [[1une]], [[1mkt]], [[1irb]] - bPLA2<br /> | ||
1b4w, 1jia – AhPLA2 - Agkistrodon halys | [[1b4w]], [[1jia]] – AhPLA2 - ''Agkistrodon halys''<br /> | ||
1a3d – PLA2 – Naja naja | [[1a3d]] – PLA2 – ''Naja naja''<br /> | ||
1ae7 – PLA2 – Notechis scutatus | [[1ae7]] – PLA2 – ''Notechis scutatus''<br /> | ||
=== PLA2+inhibitor === | === PLA2+inhibitor === | ||
3o4m, 3hsw – PLA2+inhibitor | [[3o4m]], [[3hsw]] – PLA2+inhibitor <br /> | ||
2azy, 2azz, 2b00, 2b01 – pPLA2+cholate derivative | [[2azy]], [[2azz]], [[2b00]], [[2b01]] – pPLA2+cholate derivative<br /> | ||
1y6o, 1fx9, 1fxf – pPLA2+MJ33 | [[1y6o]], [[1fx9]], [[1fxf]] – pPLA2+MJ33<br /> | ||
1l8s – pPLA2+LPC-ether | [[1l8s]] – pPLA2+LPC-ether<br /> | ||
3nju – PLA2 group I+4-methoxy-benzoic acid – | [[3nju]] – PLA2 group I+4-methoxy-benzoic acid – Andaman cobra<br /> | ||
2wq5 – PLA2+minocyclin – Indian cobra | [[2wq5]] – PLA2+minocyclin – Indian cobra<br /> | ||
3h1x, 3fo7 – IvPLA2+indomethacin | [[3h1x]], [[3fo7]] – IvPLA2+indomethacin <br /> | ||
3fg5 – IvPLA2+pentapeptide+ajmaline | [[3fg5]] – IvPLA2+pentapeptide+ajmaline<br /> | ||
3cbi – IvPLA2+anisic acid+ajmaline | [[3cbi]] – IvPLA2+anisic acid+ajmaline<br /> | ||
2qu9 – IvPLA2+eugenol | [[2qu9]] – IvPLA2+eugenol<br /> | ||
2otf – IvPLA2+atenolol | [[2otf]] – IvPLA2+atenolol<br /> | ||
1zwp - IvPLA2+nimesulide | [[1zwp]] - IvPLA2+nimesulide<br /> | ||
1th6 - IvPLA2+atropine | [[1th6]] - IvPLA2+atropine<br /> | ||
1td7 - IvPLA2+niflumic acid | [[1td7]] - IvPLA2+niflumic acid<br /> | ||
1tgm - IvPLA2+aspirin | [[1tgm]] - IvPLA2+aspirin<br /> | ||
2wg9 – rPLA2+octanoic acid | [[2wg9]] – rPLA2+octanoic acid<br /> | ||
1oxr – NsPLA2+aspirin | [[1oxr]] – NsPLA2+aspirin<br /> | ||
1bk9 – AhPLA2+PBPB | [[1bk9]] – AhPLA2+PBPB<br /> | ||
1fdk – bPLA2+MJ33 | [[1fdk]] – bPLA2+MJ33<br /> | ||
1mkv – bPLA2+transition state analog | [[1mkv]] – bPLA2+transition state analog<br /> | ||
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2o1n, 2d02, 2fnx, 1zm6, 1tdv, 1tg4, 1t37 - IvPLA2+polypeptide | [[2o1n]], [[2d02]], [[2fnx]], [[1zm6]], [[1tdv]], [[1tg4]], [[1t37]] - IvPLA2+polypeptide<br /> | ||
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3i3h, 3i3i, 3hzd, 2oqd, 1zlb, 1umv – BTX | [[3i3h]], [[3i3i]], [[3hzd]], [[2oqd]], [[1zlb]], [[1umv]] – BTX<br /> | ||
3jr8 – BTXD+Ca | [[3jr8]] – BTXD+Ca<br /> | ||
3hzw, 3i03 – BTX+BPB | [[3hzw]], [[3i03]] – BTX+BPB<br /> | ||
3iq3, 2h8i – BTX + PEG | [[3iq3]], [[2h8i]] – BTX + PEG<br /> | ||
Revision as of 15:43, 3 November 2010
Phospholipase A2 (PLA2) is an enzyme which releases fatty acids from glycerol. It is found in mammals and in snake venoms. PLA2 releases arachidonic acid from membranes causing inflammation and pain. PLA2 from the snake Bothrops jararacussu is called bothropstoxin (BTX). The images at the left and at the right correspond to one representative PLA2, i.e. the crystal structure of Phospholipase A2 from Naja naja sagittifera (1yxh).
3D Structures of Phospholipase A23D Structures of Phospholipase A2
PLA2PLA2
1qll, 2q2j – PLA2 – Bothrops pirajai
2zp3, 2zp4, 2zp5 – bPLA2 (mutant) – bovine
2qog – PLA2 – Crotalus durissus
2ph4 – PLA2 – Zhaoermia mangshanensis
2h4c, 1q6v – IvPLA2 – Indian viper
2osn, 1fe5, 1dpy – kPLA2 – krait
1g0z, 1g2x – kPLA2 (mutant)
2wg7, 2wg8 – rPLA2 – rice
1yxh – NsPLA2 – Naja sagittifera
1y6p – pPLA2 (mutant) – pig
1sfv, 1sfw, 1pir, 1pis – pPLA2 - NMR
1oz6 – PLA2 – Echis carinatus
1it4, 1it5 – PLA2 – Stretomyces violaceoruber – NMR
1mg6 – PLA2 – Agkistrodon acutus
1mc2 – PLA2 – Chinese moccasin
1c74, 1kvw, 1kvx, 1kvy, 1ceh – bPLA2 (mutant) – bovine
1une, 1mkt, 1irb - bPLA2
1b4w, 1jia – AhPLA2 - Agkistrodon halys
1a3d – PLA2 – Naja naja
1ae7 – PLA2 – Notechis scutatus
PLA2+inhibitorPLA2+inhibitor
3o4m, 3hsw – PLA2+inhibitor
2azy, 2azz, 2b00, 2b01 – pPLA2+cholate derivative
1y6o, 1fx9, 1fxf – pPLA2+MJ33
1l8s – pPLA2+LPC-ether
3nju – PLA2 group I+4-methoxy-benzoic acid – Andaman cobra
2wq5 – PLA2+minocyclin – Indian cobra
3h1x, 3fo7 – IvPLA2+indomethacin
3fg5 – IvPLA2+pentapeptide+ajmaline
3cbi – IvPLA2+anisic acid+ajmaline
2qu9 – IvPLA2+eugenol
2otf – IvPLA2+atenolol
1zwp - IvPLA2+nimesulide
1th6 - IvPLA2+atropine
1td7 - IvPLA2+niflumic acid
1tgm - IvPLA2+aspirin
2wg9 – rPLA2+octanoic acid
1oxr – NsPLA2+aspirin
1bk9 – AhPLA2+PBPB
1fdk – bPLA2+MJ33
1mkv – bPLA2+transition state analog
PLA2+polypeptidePLA2+polypeptide
2o1n, 2d02, 2fnx, 1zm6, 1tdv, 1tg4, 1t37 - IvPLA2+polypeptide
BothropstoxinBothropstoxin
3i3h, 3i3i, 3hzd, 2oqd, 1zlb, 1umv – BTX
3jr8 – BTXD+Ca
3hzw, 3i03 – BTX+BPB
3iq3, 2h8i – BTX + PEG