Phospholipase A2

File:1yxh.png

Crystal Structure of Phospholipase A2 from Naja naja sagittifera 1yxh

Phospholipase A2 (PLA2) is an enzyme which releases fatty acids from glycerol. It is found in mammals and in snake venoms. PLA2 releases arachidonic acid from membranes causing inflammation and pain. PLA2 from the snake Bothrops jararacussu is called bothropstoxin (BTX). The images at the left and at the right correspond to one representative PLA2, i.e. the crystal structure of Phospholipase A2 from Naja naja sagittifera (1yxh).

3D Structures of Phospholipase A23D Structures of Phospholipase A2

PLA2PLA2

1qll, 2q2j – PLA2 – Bothrops pirajai 2zp3, 2zp4, 2zp5 – bPLA2 (mutant) – bovine 2qog – PLA2 – Crotalus durissus 2ph4 – PLA2 – Zhaoermia mangshanensis 2h4c, 1q6v – IvPLA2 – Indian viper 2osn, 1fe5, 1dpy – kPLA2 – krait 1g0z, 1g2x – kPLA2 (mutant) 2wg7, 2wg8 – rPLA2 – rice 1yxh – NsPLA2 – Naja sagittifera 1y6p – pPLA2 (mutant) – pig 1sfv, 1sfw, 1pir, 1pis – pPLA2 - NMR 1oz6 – PLA2 – Echis carinatus 1it4, 1it5 – PLA2 – Stretomyces violaceoruber – NMR 1mg6 – PLA2 – Agkistrodon acutus 1mc2 – PLA2 – Chinese moccasin 1c74, 1kvw, 1kvx, 1kvy, 1ceh – bPLA2 (mutant) – bovine 1une, 1mkt, 1irb - bPLA2 1b4w, 1jia – AhPLA2 - Agkistrodon halys 1a3d – PLA2 – Naja naja 1ae7 – PLA2 – Notechis scutatus

PLA2+inhibitorPLA2+inhibitor

3o4m, 3hsw – PLA2+inhibitor 2azy, 2azz, 2b00, 2b01 – pPLA2+cholate derivative 1y6o, 1fx9, 1fxf – pPLA2+MJ33 1l8s – pPLA2+LPC-ether 3nju – PLA2 group I+4-methoxy-benzoic acid – Andman cobra 2wq5 – PLA2+minocyclin – Indian cobra 3h1x, 3fo7 – IvPLA2+indomethacin 3fg5 – IvPLA2+pentapeptide+ajmaline 3cbi – IvPLA2+anisic acid+ajmaline 2qu9 – IvPLA2+eugenol 2otf – IvPLA2+atenolol 1zwp - IvPLA2+nimesulide 1th6 - IvPLA2+atropine 1td7 - IvPLA2+niflumic acid 1tgm - IvPLA2+aspirin 2wg9 – rPLA2+octanoic acid 1oxr – NsPLA2+aspirin 1bk9 – AhPLA2+PBPB 1fdk – bPLA2+MJ33 1mkv – bPLA2+transition state analog

PLA2+polypeptidePLA2+polypeptide

2o1n, 2d02, 2fnx, 1zm6, 1tdv, 1tg4, 1t37 - IvPLA2+polypeptide

BothropstoxinBothropstoxin

3i3h, 3i3i, 3hzd, 2oqd, 1zlb, 1umv – BTX 3jr8 – BTXD+Ca 3hzw, 3i03 – BTX+BPB 3iq3, 2h8i – BTX + PEG