2vu3: Difference between revisions

Revision as of 11:07, 3 November 2010

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File:2vu3.png

Template:STRUCTURE 2vu3

IDENTIFICATION OF N-(4-PIPERIDINYL)-4-(2,6-DICHLOROBENZOYLAMINO)-1H-PYRAZOLE-3-CARBOXAMIDE (AT7519), A NOVEL CYCLIN DEPENDENT KINASE INHIBITOR USING FRAGMENT-BASED X-RAY CRYSTALLOGRAPHY AND STRUCTURE BASED DRUG DESIGN.IDENTIFICATION OF N-(4-PIPERIDINYL)-4-(2,6-DICHLOROBENZOYLAMINO)-1H-PYRAZOLE-3-CARBOXAMIDE (AT7519), A NOVEL CYCLIN DEPENDENT KINASE INHIBITOR USING FRAGMENT-BASED X-RAY CRYSTALLOGRAPHY AND STRUCTURE BASED DRUG DESIGN.

Template:ABSTRACT PUBMED 18656911

About this StructureAbout this Structure

2VU3 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

^{[xtra 1]}

↑ Wyatt PG, Woodhead AJ, Berdini V, Boulstridge JA, Carr MG, Cross DM, Davis DJ, Devine LA, Early TR, Feltell RE, Lewis EJ, McMenamin RL, Navarro EF, O'Brien MA, O'Reilly M, Reule M, Saxty G, Seavers LC, Smith DM, Squires MS, Trewartha G, Walker MT, Woolford AJ. Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design. J Med Chem. 2008 Aug 28;51(16):4986-99. Epub 2008 Jul 26. PMID:18656911 doi:10.1021/jm800382h

Page seeded by OCA on Wed Nov 3 11:18:24 2010

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OCA

[1] Wyatt PG, Woodhead AJ, Berdini V, Boulstridge JA, Carr MG, Cross DM, Davis DJ, Devine LA, Early TR, Feltell RE, Lewis EJ, McMenamin RL, Navarro EF, O'Brien MA, O'Reilly M, Reule M, Saxty G, Seavers LC, Smith DM, Squires MS, Trewartha G, Walker MT, Woolford AJ. Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design. J Med Chem. 2008 Aug 28;51(16):4986-99. Epub 2008 Jul 26. PMID:18656911 doi:10.1021/jm800382h

[xtra 1]

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 ===IDENTIFICATION OF N-(4-PIPERIDINYL)-4-(2,6-DICHLOROBENZOYLAMINO)-1H-PYRAZOLE-3-CARBOXAMIDE (AT7519), A NOVEL CYCLIN DEPENDENT KINASE INHIBITOR USING FRAGMENT-BASED X-RAY CRYSTALLOGRAPHY AND STRUCTURE BASED DRUG DESIGN.===
+<!--
+The line below this paragraph, {{ABSTRACT_PUBMED_18656911}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 18656911 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_18656911}}
 ==About this Structure==
-VU3 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VU3 OCA].
+VU3 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VU3 OCA].
+==Reference==
+<ref group="xtra">PMID:18656911</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
 [[Category: Berdini, V.]]
@@ Line 33: / Line 42: @@
 [[Category: Saxty, G.]]
 [[Category: Seavers, L C.A.]]
-[[Category: Smith, D M.]]
+[[Category: Smith, D.]]
 [[Category: Squires, M S.]]
 [[Category: Trewartha, G.]]
 [[Category: Walker, M T.]]
 [[Category: Woodhead, A J.]]
-[[Category: Woolford, A J.A.]]
+[[Category: Woolford, A J.]]
 [[Category: Wyatt, P G.]]
-[[Category: Atp-binding]]
 [[Category: Cell cycle]]
-[[Category: Cell division]]
-[[Category: Fragment screening]]
-[[Category: Kinase]]
 [[Category: Mitosis]]
-[[Category: Nucleotide-binding]]
-[[Category: Phosphoprotein]]
-[[Category: Phosphorylation]]
-[[Category: Polymorphism]]
-[[Category: Protein kinase]]
 [[Category: Serine/threonine protein kinase]]
-[[Category: Serine/threonine-protein kinase]]
-[[Category: Structure based drug design]]
 [[Category: Transferase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 18:52:35 2009''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov  3 11:18:24 2010''