2bjo: Difference between revisions
New page: left|200px<br /><applet load="2bjo" size="450" color="white" frame="true" align="right" spinBox="true" caption="2bjo, resolution 2.101Å" /> '''CRYSTAL STRUCTURE O... |
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[[Image:2bjo.gif|left|200px]]<br /><applet load="2bjo" size=" | [[Image:2bjo.gif|left|200px]]<br /><applet load="2bjo" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="2bjo, resolution 2.101Å" /> | caption="2bjo, resolution 2.101Å" /> | ||
'''CRYSTAL STRUCTURE OF THE ORGANIC HYDROPEROXIDE RESISTANCE PROTEIN OHRB OF BACILLUS SUBTILIS'''<br /> | '''CRYSTAL STRUCTURE OF THE ORGANIC HYDROPEROXIDE RESISTANCE PROTEIN OHRB OF BACILLUS SUBTILIS'''<br /> | ||
==Overview== | |||
The crystal structure of the fully oxidized form of the Bacillus subtilis, organic hydroperoxide-resistance (OhrB) protein is reported at 2.1 A, resolution. The electron density reveals an intact catalytic disulfide, bond (Cys55-Cys119) in each of the two molecules, which are intertwined, into a canonical obligate dimer. However, the stereochemistry of the, disulfides is unorthodox and strained, suggesting that they are sensitive, to reducing agents. A deep solvent-accessible gorge reaching Cys55 may, represent the access route for the reductant. | |||
==About this Structure== | ==About this Structure== | ||
2BJO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http:// | 2BJO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BJO OCA]. | ||
==Reference== | |||
Structure of the Bacillus subtilis OhrB hydroperoxide-resistance protein in a fully oxidized state., Cooper DR, Surendranath Y, Devedjiev Y, Bielnicki J, Derewenda ZS, Acta Crystallogr D Biol Crystallogr. 2007 Dec;63(Pt 12):1269-73. Epub 2007, Nov 16. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18084074 18084074] | |||
[[Category: Bacillus subtilis]] | [[Category: Bacillus subtilis]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: oxidoreductase]] | [[Category: oxidoreductase]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 11:21:51 2008'' | ||
Revision as of 12:21, 23 January 2008
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CRYSTAL STRUCTURE OF THE ORGANIC HYDROPEROXIDE RESISTANCE PROTEIN OHRB OF BACILLUS SUBTILIS
OverviewOverview
The crystal structure of the fully oxidized form of the Bacillus subtilis, organic hydroperoxide-resistance (OhrB) protein is reported at 2.1 A, resolution. The electron density reveals an intact catalytic disulfide, bond (Cys55-Cys119) in each of the two molecules, which are intertwined, into a canonical obligate dimer. However, the stereochemistry of the, disulfides is unorthodox and strained, suggesting that they are sensitive, to reducing agents. A deep solvent-accessible gorge reaching Cys55 may, represent the access route for the reductant.
About this StructureAbout this Structure
2BJO is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.
ReferenceReference
Structure of the Bacillus subtilis OhrB hydroperoxide-resistance protein in a fully oxidized state., Cooper DR, Surendranath Y, Devedjiev Y, Bielnicki J, Derewenda ZS, Acta Crystallogr D Biol Crystallogr. 2007 Dec;63(Pt 12):1269-73. Epub 2007, Nov 16. PMID:18084074
Page seeded by OCA on Wed Jan 23 11:21:51 2008