User:Eric Martz/Sandbox 0: Difference between revisions
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A piece of string, or a protein chain, is deemed to contain a knot when pulling on the ends would leave a knot. When the ends of most folded protein chains are "pulled", they resolve to a straight chain between the pulled ends: no knot remains. In this article, only knots in the peptide-bonded amino acid chain are considered; knots resulting from disulfide bonds or hydrogen bonds are excluded. Knots in protein chains are rare, and the mechanisms by which they form and their functions remain subjects of experimentation and discussion<ref name="taylor2000">PMID: 10972297</ref><ref name="taylor2007">PMID: 17500039</ref><ref>PMID: 19186124</ref><ref>PMID: 19015517</ref>. A dramatic protein knot, discovered in 2000<ref name="taylor2000" />, is illustrated here. | A piece of string, or a protein chain, is deemed to contain a knot when pulling on the ends would leave a knot. When the ends of most folded protein chains are "pulled", they resolve to a straight chain between the pulled ends: no knot remains. In this article, only knots in the peptide-bonded amino acid chain are considered; knots resulting from disulfide bonds or hydrogen bonds are excluded. Knots in protein chains are rare, and the mechanisms by which they form and their functions remain subjects of experimentation and discussion<ref name="taylor2000">PMID: 10972297</ref><ref name="taylor2007">PMID: 17500039</ref><ref>PMID: 19186124</ref><ref>PMID: 19015517</ref>. A dramatic protein knot, discovered in 2000<ref name="taylor2000" />, is illustrated here. | ||
==Figure of eight knot in acetohydroxy acid isomeroreductase== | ==Figure-of-eight knot in acetohydroxy acid isomeroreductase== | ||
<table class="wikitable" align="right" width="260"><tr><td>[[Image:Overhand knot.jpg]]</td><td>[[Image:Figure-of-eight-knot.jpg]]</td></tr><tr><td>Trefoil (overhand, [http://en.wikipedia.org/wiki/Crossing_number_(knot_theory) 3<sub>1</sub>]) knot.</td><td>Figure-of-eight knot ([http://en.wikipedia.org/wiki/Crossing_number_(knot_theory) 4<sub>1</sub>])</td></tr></table> | <table class="wikitable" align="right" width="260"><tr><td>[[Image:Overhand knot.jpg]]</td><td>[[Image:Figure-of-eight-knot.jpg]]</td></tr><tr><td>Trefoil (overhand, [http://en.wikipedia.org/wiki/Crossing_number_(knot_theory) 3<sub>1</sub>]) knot.</td><td>Figure-of-eight knot ([http://en.wikipedia.org/wiki/Crossing_number_(knot_theory) 4<sub>1</sub>])</td></tr></table> | ||