Thermolysin: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel

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 [[Image:3dnz.jpg|left|200px|thumb|Crystal Structure of Thermolysin [[3dnz]]]]
-{{STRUCTURE_3dnz|  PDB=3dnz  | SIZE=300| SCENE= |right|CAPTION=Thermolysin [[3dnz]] }}
+{{STRUCTURE_3dnz|  PDB=3dnz  | SIZE=300| SCENE=Thermolysin/Cv/1 |right|CAPTION=Thermolysin [[3dnz]] }}
+Thermolysin (TML) is a thermostable metalloproteinase enzyme from ''Bacillus thermoproteolyticus''.  It catalyzes the hydrolysis of peptide bonds  containing hydrophobic residues. The images at the left and at the right correspond to one representative Thermolysin ([[3dnz]]).
+{{TOC limit|limit=2}}
+== 3D Structures of Thermolysin ==
+== Thermolysin ==
+[[2whz]], [[3fvp]], [[3dnz]], [[3do0]], [[3do1]], [[3do2]], [[2g4z]], [[2a7g]], [[1gxw]], [[1kei]], [[1l3f]], [[1tlx]], [[2tlx]], [[8tln]] – TML<br />
+[[1trl]] - TML residues 255-316 – NMR<br />
+[[3fxs]], [[3fbo]], [[3eim]], [[1lna]], [[1lnb]], [[1lnc]], [[1lnd]], [[1lne]], [[1lnf]] - TML residues 233-548+metal ion replacing Ca<br />
+=== TML+transition state analog ===
+[[1tlp]], [[1tmn]], [[2tmn]], [[4tmn]], [[5tmn]] – TML+transition state analog<br />
+=== TML+ dipeptide ===
+[[2wi0]], [[3tmn]] – TML+ dipeptide <br />
+[[3fgd]] - TML residues 233-548+dipeptide<br />
+=== TML+inhibitor ===
+[[1fjo]], [[1fj3]], [[1fjq]], [[1fjt]], [[1fju]], [[1fjv]], [[1fjw]], [[4tli]], [[5tli]], [[6tli]], [[7tli]], [[8tli]], [[1tli]], [[2tli]], [[3tli]] – TML soaked in organic solvents<br />
+[[3fv4]], [[3fxp]], [[3flf]], [[3fb0]], [[3fcq]], [[3f28]], [[3f2p]] – TML residues 233-548+inhibitor<br />
+[[3fwd]], [[3for]], [[1y3g]], [[1zdp]], [[1z9g]], [[1pes]], [[1pe7]], [[1pe8]], [[1os0]], [[1kto]], [[1ks7]], [[1kro]], [[1kr6]], [[1kkk]], [[1kjo]], [[1kjp]], [[1qf0]], [[1qf1]], [[1qf2]], [[1hyt]], [[1thl]], [[6tmn]], [[7tln]], [[4tln]], [[5tln]] – TML+inhibitor<br />