1e7q: Difference between revisions
New page: left|200px<br /> <applet load="1e7q" size="450" color="white" frame="true" align="right" spinBox="true" caption="1e7q, resolution 1.6Å" /> '''GDP 4-KETO-6-DEOXY-D... |
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==About this Structure== | ==About this Structure== | ||
1E7Q is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]] with SO4, NAP, UVW and TRS as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1E7Q OCA]]. | 1E7Q is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]] with SO4, NAP, UVW and TRS as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Sites: AC1 and AC2. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1E7Q OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: sdr]] | [[Category: sdr]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:03:51 2007'' | ||
Revision as of 11:59, 30 October 2007
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GDP 4-KETO-6-DEOXY-D-MANNOSE EPIMERASE REDUCTASE S107A
OverviewOverview
GDP-4-keto-6-deoxy-d-mannose epimerase/reductase is a bifunctional enzyme, responsible for the last step in the biosynthesis of GDP-l-fucose, the, substrate of fucosyl transferases. Several cell-surface antigens, including the leukocyte Lewis system and cell-surface antigens in, pathogenic bacteria, depend on the availability of GDP-l-fucose for their, expression. Therefore, the enzyme is a potential target for therapy in, pathological states depending on selectin-mediated cell-to-cell, interactions. Previous crystallographic investigations have shown that, GDP-4-keto-6-deoxy-d-mannose epimerase/reductase belongs to the, short-chain dehydrogenase/reductase protein homology family. The enzyme, active-site region is at the interface of an N-terminal NADPH-binding, domain and a C-terminal ... [(full description)]
About this StructureAbout this Structure
1E7Q is a [Single protein] structure of sequence from [Escherichia coli] with SO4, NAP, UVW and TRS as [ligands]. Structure known Active Sites: AC1 and AC2. Full crystallographic information is available from [OCA].
ReferenceReference
Probing the catalytic mechanism of GDP-4-keto-6-deoxy-d-mannose Epimerase/Reductase by kinetic and crystallographic characterization of site-specific mutants., Rosano C, Bisso A, Izzo G, Tonetti M, Sturla L, De Flora A, Bolognesi M, J Mol Biol. 2000 Oct 13;303(1):77-91. PMID:11021971
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