P53: Difference between revisions
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The figure at the left shows the surface charge of the p53 DNA-binding domain. It is rich in arginine amino acids that interact with DNA, and this causes its surface to be positively charged. This domain recognizes specific regulatory sites on the DNA. The flexible structure of p53 allows it to bind to many different variants of binding sites, allowing it to regulate transcription at many places in the genome. | The figure at the left shows the surface charge of the p53 DNA-binding domain. It is rich in arginine amino acids that interact with DNA, and this causes its surface to be positively charged. This domain recognizes specific regulatory sites on the DNA. The flexible structure of p53 allows it to bind to many different variants of binding sites, allowing it to regulate transcription at many places in the genome. | ||
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zinc plays a role in stabilizing the two loops through | zinc plays a role in stabilizing the two loops through | ||
coordination. The Zn has been represented as a red sphere in the figure at the right. | coordination. The Zn has been represented as a red sphere in the figure at the right. | ||
==Additional Resources== | ==Additional Resources== | ||
For additional information, see: [[Cancer]]<br /> | For additional information, see: [[Cancer]]<br /> | ||