User:Eric Martz/Sandbox 0: Difference between revisions

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==Figure of eight knot in acetohydroxy acid isomeroreductase==

<table class="wikitable" align="right"><tr><td>[[Image:Overhand knot.jpg]]</td></tr></table>

<table class="wikitable" align="right"><tr><td>[[Image:Overhand knot.jpg]]</td><td>[[Image:Figure-of-eight-knot.jpg]]</td></tr><tr><td>Trefoil (overhand) knot.</td><td>Figure-of-eight knot</td></tr></table>

William R. Taylor developed an algorithm for detecting knots in protein backbones, which he reported in 2000<ref name="taylor2000">PMID: 10972297</ref>. He scanned 3,440 sequence-different published protein structures from the [[Protein Data Bank]]. Only eight genuine knots were found, most of which were simple [http://en.wikipedia.org/wiki/Trefoil_knot trefoil knots] ([http://en.wikipedia.org/wiki/Overhand_knot overhand knots]) and had been previously described. However several knots were detected in proteins not previously recognized as knotted. One was in acetohydroxy acid isomeroreductase ("AAIR", [[1yve]], [[1qmg]]) , and was particularly interesting because of how deeply it sits in the folded protein backbone (far away from the ends) and because it is a more complicated [http://en.wikipedia.org/wiki/Figure-eight_knot_(mathematics) figure-of-eight knot].

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 ==Figure of eight knot in acetohydroxy acid isomeroreductase==
-<table class="wikitable" align="right"><tr><td>[[Image:Overhand knot.jpg]]</td></tr></table>
+<table class="wikitable" align="right"><tr><td>[[Image:Overhand knot.jpg]]</td><td>[[Image:Figure-of-eight-knot.jpg]]</td></tr><tr><td>Trefoil (overhand) knot.</td><td>Figure-of-eight knot</td></tr></table>
 William R. Taylor developed an algorithm for detecting knots in protein backbones, which he reported in 2000<ref name="taylor2000">PMID: 10972297</ref>. He scanned 3,440 sequence-different published protein structures from the [[Protein Data Bank]]. Only eight genuine knots were found, most of which were simple [http://en.wikipedia.org/wiki/Trefoil_knot trefoil knots] ([http://en.wikipedia.org/wiki/Overhand_knot overhand knots]) and had been previously described. However several knots were detected in proteins not previously recognized as knotted. One was in acetohydroxy acid isomeroreductase ("AAIR", [[1yve]], [[1qmg]]) , and was particularly interesting because of how deeply it sits in the folded protein backbone (far away from the ends) and because it is a more complicated [http://en.wikipedia.org/wiki/Figure-eight_knot_(mathematics) figure-of-eight knot].