Sandbox 250: Difference between revisions
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The <scene name='Sandbox_250/Ache_ach/4'> 14 aromatic residues</scene> that line the active site gorge are tyr70, trp84, trp120, tyr121, tyr130, trp233, trp279, phe288, phe290, phe330, phe331, tyr334, trp432 and tyr442. | The <scene name='Sandbox_250/Ache_ach/4'> 14 aromatic residues</scene> that line the active site gorge are tyr70, trp84, trp120, tyr121, tyr130, trp233, trp279, phe288, phe290, phe330, phe331, tyr334, trp432 and tyr442. | ||
The Peripheral Anionic Site(PAS) includes <scene name='Sandbox_250/Ache_ach/ | The Peripheral Anionic Site(PAS) includes <scene name='Sandbox_250/Ache_ach/11'>Tyr279, Tyr70 and Tyr121</scene>. Initially, the positively charged quaternary ammonium ion of ACh is attracted to and binds to the <scene name='Sandbox_250/Ache_ach/12'>PAS of AChE</scene>, highlighted in yellow. | ||
The Catalytic Anionic Site(CAS) includes <scene name='Sandbox_250/Ache_ach/ | The Catalytic Anionic Site(CAS) includes <scene name='Sandbox_250/Ache_ach/13'>Trp84 and Phe330</scene>. The | ||
<scene name='Sandbox_250/Ache_ach/10'>CAS</scene>, highlighted in red, holds ACh in the optimal position for hydrolysis by interacting with the quaternary ammonium ion of ACh. | <scene name='Sandbox_250/Ache_ach/10'>CAS</scene>, highlighted in red, holds ACh in the optimal position for hydrolysis by interacting with the quaternary ammonium ion of ACh. | ||