Insecticidal delta-endotoxin Cyt2Ba from Bacillus thuringiensis: Difference between revisions
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The crystal structure of monomeric Cyt2Ba is the first structure of a [http://en.wikipedia.org/wiki/Toxicity toxic] form of the Cyt family. Its structure is [http://en.wikipedia.org/wiki/Homology_(biology) homologous] to the corresponding region of Cyt2Aa and to that of VVA2. This structural comparison shows that the toxicity of Cyt2Ba, Cyt2Aa and VVA2 is an inherent property of the monomer and not the result of secondary structure rearrangement upon cleavage. Solving the 3D structure of these proteins extends the knowledge of the cytolytic machinery of pore-forming toxins and helps in designing novel membrane-active cytotoxins. | The crystal structure of monomeric Cyt2Ba is the first structure of a [http://en.wikipedia.org/wiki/Toxicity toxic] form of the Cyt family. Its structure is [http://en.wikipedia.org/wiki/Homology_(biology) homologous] to the corresponding region of Cyt2Aa and to that of VVA2. This structural comparison shows that the toxicity of Cyt2Ba, Cyt2Aa and VVA2 is an inherent property of the monomer and not the result of secondary structure rearrangement upon cleavage. Solving the 3D structure of these proteins extends the knowledge of the cytolytic machinery of pore-forming toxins and helps in designing novel membrane-active cytotoxins. | ||
==Additional Resources== | |||
For additional information, see: [[Toxins]] | |||
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