1dz8: Difference between revisions
New page: left|200px<br /> <applet load="1dz8" size="450" color="white" frame="true" align="right" spinBox="true" caption="1dz8, resolution 1.9Å" /> '''OXYGEN COMPLEX OF P4... |
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==About this Structure== | ==About this Structure== | ||
1DZ8 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Pseudomonas_putida Pseudomonas putida]] with K, HEM, OXY, CAM and TRS as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DZ8 OCA]]. | 1DZ8 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Pseudomonas_putida Pseudomonas putida]] with K, HEM, OXY, CAM and TRS as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Sites: K1, K2, K3 and O2. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DZ8 OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: mono-oxygenase]] | [[Category: mono-oxygenase]] | ||
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Revision as of 11:56, 30 October 2007
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OXYGEN COMPLEX OF P450CAM FROM PSEUDOMONAS PUTIDA
OverviewOverview
Members of the cytochrome P450 superfamily catalyze the addition of, molecular oxygen to nonactivated hydrocarbons at physiological, temperature-a reaction that requires high temperature to proceed in the, absence of a catalyst. Structures were obtained for three intermediates in, the hydroxylation reaction of camphor by P450cam with trapping techniques, and cryocrystallography. The structure of the ferrous dioxygen adduct of, P450cam was determined with 0.91 angstrom wavelength x-rays; irradiation, with 1.5 angstrom x-rays results in breakdown of the dioxygen molecule to, an intermediate that would be consistent with an oxyferryl species. The, structures show conformational changes in several important residues and, reveal a network of bound water molecules that may provide the protons, ... [(full description)]
About this StructureAbout this Structure
1DZ8 is a [Single protein] structure of sequence from [Pseudomonas putida] with K, HEM, OXY, CAM and TRS as [ligands]. Structure known Active Sites: K1, K2, K3 and O2. Full crystallographic information is available from [OCA].
ReferenceReference
The catalytic pathway of cytochrome p450cam at atomic resolution., Schlichting I, Berendzen J, Chu K, Stock AM, Maves SA, Benson DE, Sweet RM, Ringe D, Petsko GA, Sligar SG, Science. 2000 Mar 3;287(5458):1615-22. PMID:10698731
Page seeded by OCA on Tue Oct 30 11:01:33 2007