1uw3: Difference between revisions
New page: left|200px<br /> <applet load="1uw3" size="450" color="white" frame="true" align="right" spinBox="true" caption="1uw3, resolution 2.05Å" /> '''THE CRYSTAL STRUCTU... |
No edit summary |
||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
1UW3 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Ovis_aries Ovis aries]] with PO4 and GTT as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UW3 OCA]]. | 1UW3 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Ovis_aries Ovis aries]] with PO4 and GTT as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: GTT. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UW3 OCA]]. | ||
==Reference== | ==Reference== | ||
| Line 29: | Line 29: | ||
[[Category: transmissible spongiform encephalopathy]] | [[Category: transmissible spongiform encephalopathy]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:01:01 2007'' | ||
Revision as of 11:56, 30 October 2007
|
THE CRYSTAL STRUCTURE OF THE GLOBULAR DOMAIN OF SHEEP PRION PROTEIN
OverviewOverview
The prion protein PrP is a naturally occurring polypeptide that becomes, transformed from a normal conformation to that of an aggregated form, characteristic of pathological states in fatal transmissible spongiform, conditions such as Creutzfeld-Jacob Disease and Bovine Spongiform, Encephalopathy. We report the crystal structure, at 2 A resolution, of, residues 123-230 of the C-terminal globular domain of the ARQ allele of, sheep prion protein (PrP). The asymmetric unit contains a single molecule, whose secondary structure and overall organisation correspond to those, structures of PrPs from various mammalian species determined by NMR. The, globular domain shows a close association of helix-1, the C-terminal, portion of helix-2 and the N-terminal portion of helix-3, bounded by the, ... [(full description)]
About this StructureAbout this Structure
1UW3 is a [Single protein] structure of sequence from [Ovis aries] with PO4 and GTT as [ligands]. Structure known Active Site: GTT. Full crystallographic information is available from [OCA].
ReferenceReference
The crystal structure of the globular domain of sheep prion protein., Haire LF, Whyte SM, Vasisht N, Gill AC, Verma C, Dodson EJ, Dodson GG, Bayley PM, J Mol Biol. 2004 Mar 5;336(5):1175-83. PMID:15037077
Page seeded by OCA on Tue Oct 30 11:01:01 2007