2vex: Difference between revisions

Revision as of 11:45, 23 January 2008

CRYSTAL STRUCUTRE OF PROTEIN TYROSINE PHOSPHATASE 1B IN COMPLEX WITH AN ISOTHIAZOLIDINONE-CONTAINING INHIBITOR

OverviewOverview

The structure-based design and synthesis of isothiazolidinone (IZD), inhibitors of PTP1B containing imidazoles and imidazolines and their, modification to interact with the B site of PTP1B are described here. The, X-ray crystal structures of 3I and 4I complexed with PTP1B were solved and, revealed the inhibitors are interacting extensively with the B site of the, enzyme.

About this StructureAbout this Structure

2VEX is a Single protein structure of sequence from Homo sapiens with and as ligands. Active as Protein-tyrosine-phosphatase, with EC number 3.1.3.48 Known structural/functional Sites: and . Full crystallographic information is available from OCA.

ReferenceReference

Isothiazolidinone inhibitors of PTP1B containing imidazoles and imidazolines., Douty B, Wayland B, Ala PJ, Bower MJ, Pruitt J, Bostrom L, Wei M, Klabe R, Gonneville L, Wynn R, Burn TC, Liu PC, Combs AP, Yue EW, Bioorg Med Chem Lett. 2008 Jan 1;18(1):66-71. Epub 2007 Nov 9. PMID:18037290

Page seeded by OCA on Wed Jan 23 10:45:54 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:2vex.jpg|left|200px]]<br /><applet load="2vex" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:2vex.jpg|left|200px]]<br /><applet load="2vex" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="2vex, resolution 2.2&Aring;" />
 '''CRYSTAL STRUCUTRE OF PROTEIN TYROSINE PHOSPHATASE 1B IN COMPLEX WITH AN ISOTHIAZOLIDINONE-CONTAINING INHIBITOR'''<br />
-==Disease==
+==Overview==
-Known diseases associated with this structure: Abdominal body fat distribution, modifier of OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176885 176885]], Insulin resistance, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176885 176885]]
+The structure-based design and synthesis of isothiazolidinone (IZD), inhibitors of PTP1B containing imidazoles and imidazolines and their, modification to interact with the B site of PTP1B are described here. The, X-ray crystal structures of 3I and 4I complexed with PTP1B were solved and, revealed the inhibitors are interacting extensively with the B site of the, enzyme.
 ==About this Structure==
-VEX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with MG and IZ4 as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] Known structural/functional Sites: <scene name='pdbsite=AC1:Iz4 Binding Site For Chain A'>AC1</scene> and <scene name='pdbsite=AC2:Mg Binding Site For Chain A'>AC2</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2VEX OCA].
+VEX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=IZ4:'>IZ4</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] Known structural/functional Sites: <scene name='pdbsite=AC1:Iz4 Binding Site For Chain A'>AC1</scene> and <scene name='pdbsite=AC2:Mg Binding Site For Chain A'>AC2</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VEX OCA].
+==Reference==
+Isothiazolidinone inhibitors of PTP1B containing imidazoles and imidazolines., Douty B, Wayland B, Ala PJ, Bower MJ, Pruitt J, Bostrom L, Wei M, Klabe R, Gonneville L, Wynn R, Burn TC, Liu PC, Combs AP, Yue EW, Bioorg Med Chem Lett. 2008 Jan 1;18(1):66-71. Epub 2007 Nov 9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18037290 18037290]
 [[Category: Homo sapiens]]
 [[Category: Protein-tyrosine-phosphatase]]
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 [[Category: protein phosphatase]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 20:36:25 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 10:45:54 2008''