Sandbox 250: Difference between revisions

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===='''Features of the Substrate Traffic Story: AChE/ACh'''====
===='''Features of the Substrate Traffic Story: AChE/ACh'''====


AChE is an alpha/beta hydrolase fold with an amino acid sequence of 4-535. The <scene name='Sandbox/2ace/3'>alpha carbon backbone</scene> of AChE has ? alpha helices and ? beta sheets.
AChE is an alpha/beta hydrolase fold with an amino acid sequence of 4-535. The <scene name='Sandbox_250/Ache_ach/1'>alpha carbon backbone</scene> in complex with acetylcholine is shown here in green.


The <scene name='Sandbox/Ache_ach/15'>14 aromatic residues</scene> that line the active site gorge are tyr70, trp84, trp120, tyr121, tyr130, trp233, trp279, phe288, phe290, phe330, phe331, tyr334, trp432 and tyr442.
The <scene name='Sandbox/Ache_ach/15'>14 aromatic residues</scene> that line the active site gorge are tyr70, trp84, trp120, tyr121, tyr130, trp233, trp279, phe288, phe290, phe330, phe331, tyr334, trp432 and tyr442.

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Joel L. Sussman, Allison Granberry, Jaime Prilusky