Proteasome: Difference between revisions
New page: left|200px|thumb|Crystal Structure of Proteasome, [[3gpt]] {{STRUCTURE_3gpt| PDB=3gpt | SIZE=300| SCENE= |right|CAPTION=Proteasome, 3gpt }} Proteasome (PRTS) are... |
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Proteasome (PRTS) are large protein complexes which degrade unneeded proteins into small polypeptides. The 26S PRTS is composed of a central 20S core particle which contains 4 stacked rings each with several members and two 19S caps. The core particle two outer rings contain 7 alpha subunits which form the PRTS gate. The two inner rings contain 6 beta subunits with protease activity. The 19S cap is composed of a base with 10 proteins six of which are ATPases and a lid which contains 9 proteins which binds polyubiquitin. The images at the left and at the right correspond to one representative Proteasome, ''i.e.'' the crystal structure of yeast Proteasome ([[3gpt]]). | [[Proteasome]] (PRTS) are large protein complexes which degrade unneeded proteins into small polypeptides. The 26S PRTS is composed of a central 20S core particle which contains 4 stacked rings each with several members and two 19S caps. The core particle two outer rings contain 7 alpha subunits which form the PRTS gate. The two inner rings contain 6 beta subunits with protease activity. The 19S cap is composed of a base with 10 proteins six of which are ATPases and a lid which contains 9 proteins which binds polyubiquitin. The images at the left and at the right correspond to one representative Proteasome, ''i.e.'' the crystal structure of yeast Proteasome ([[3gpt]]). | ||
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== 3D Structures of Proteasome == | == 3D Structures of Proteasome == | ||
=== 20S particle === | |||
[[3mfe]], [[3mi0]], [[2fhg]] – Mt20S core – ''Mycobacterium tuberculosis''<br /> | |||
[[3gpt]], [[3gpw]], [[1g0u]] – y20S core - yeast<br /> | |||
[[1ryp]] - y20S core (mutant)<br /> | |||
[[3mka]], [[3hfa]] – Mt20S core (mutant)<br /> | |||
[[3c91]], [[3c92]], [[1pma]] – Ta20S core - ''Themoplasma acidophilum''<br /> | |||
[[3h4p]] – 20S core – ''Methanocaldococcus janaschii''<br /> | |||
[[2h6j]], [[1q5r]] – Re20S core (mutant) – ''Rhodococcus erythropolis''<br /> | |||
[[1q5q]] - Re20S core<br /> | |||
[[1j2q]] – Af20S core - ''Archaeoglobus fulgidus''<br /> | |||
[[1iru]] – 20S core - bovine<br /> | |||
=== 20S+activator protein === | |||
2ku1, 2ku2 – Taa-PRTS chains A-G | [[1vsy]], [[1l5q]] – y20S core+ Blm10 <br /> | ||
3fp9 – MtATPase chains A-L | [[1z7q]], [[1fnt]] – y20S core+PA26<br /> | ||
1j2p – Af | [[3ipm]], [[3jrm]], [[3jse]], [[3jtl]], [[1ya7]], [[1yar]], [[1yau]] - Taa-PRTS chains A-G+ Tab-PRTS chains H-N+PA26 chains O-U <br /> | ||
=== 20S+inhibitor === | |||
[[3hye]], [[3gpj]], [[3dy3]], [[3dy4]], [[3e47]], [[3d29]], [[3zcy]], [[3bdm]], [[2gpl]], [[2fak]], [[2f16]], [[1jd2]], [[1g65]] – y20S core+inhibitor<br /> | |||
[[3h6f]], [[3h6i]], [[3hf9]], [[2fhh]] – Mt20S core+inhibitor<br /> | |||
=== Partial 20S === | |||
[[2ku1]], [[2ku2]] – Taa-PRTS chains A-G <br /> | |||
[[3fp9]] – MtATPase chains A-L<br /> | |||
[[1j2p]] – Af α subunit<br /> | |||
