Titin: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, David Canner, Michal Harel, Jaime Prilusky

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 [[Image:2rik.png|left|200px|thumb|Crystal Structure of I-band fragment I67-I69 from rabbit titin, [[2rik]]]]
 {{STRUCTURE_2rik|  PDB=2rik  | SIZE=300| SCENE= |right|CAPTION=I-band fragment I67-I69 from rabbit titin, [[2rik]] }}
+[[Titin]] (TTN) is the largest known protein.  The human TTN contains 34,350 residues.  It is responsible for the passive elasticity of muscle.  It has 244 domains connected by unstructured regions.  The domains unfold when TTN is stretched. The images at the left and at the right correspond to one representative titin, ''i.e.'' the crystal structure of I-band fragment I67-I69 from rabbit titin ([[2rik]]).
+{{TOC limit|limit=2}}
+== 3D Structures of Titin ==
+[[2wp3]], [[2wwm]], [[3knb]] – hTTN residues 34252-34350+obscuring-like protein 1 fragment – human<br />
+[[2wwk]] - hTTN residues 34252-34350+obscuring-like protein 1 fragment (mutant)<br />
+[[2rq8]] – hTTN residues 12677-12765 (mutant) – NMR<br />
+[[1tit]], [[1tiu]] - hTTN I27 – NMR<br />
+[[2rik]] – rTTN I67-I69 – rabbit<br />
+[[2rjm]] - rTTN I67-I69 (mutant)<br />
+[[3b43]] - rTTN I65-I70<br />
+[[2j8h]], [[2j8o]], [[2ill]] – hTTN  residues 24430-24623<br />
+[[2nzi]] – hTTN residues 31854-32155<br />
+[[2bk8]] – hTTN residues 25073-25166<br />
+[[1waa]] - hTTN residues 12801-12889<br />
+[[2f8v]], [[1ya5]] - hTTN residues 1-196+telethonin<br />
+[[2a38]] - hTTN residues 1-194<br />
+[[1g1c]] - hTTN residues 2027-2125<br />
+[[1h8b]] – rTTN residues 648-698+h Actinin 2 EF hands 3&4<br />
+[[1bpv]] – hTTN A71 – NMR<br />
+[[1tki]] – hTTN serine kinase fragment<br />
+[[1nct]], [[1ncu]] – hTTN M5 – NMR<br />
+[[1tnm]], [[1tnn]] – hTTN M5<br />