Porin: Difference between revisions
No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:Ompc.png|left|250px|thumb|Crystal structure of Porin OmpC from ''E. coli'', [[2j1n]]]] | [[Image:Ompc.png|left|250px|thumb|Crystal structure of Porin OmpC from ''E. coli'', [[2j1n]]]] | ||
{{STRUCTURE_2j1n| PDB=2j1n | SIZE=300| SCENE=Porin/Cv/1 |right|CAPTION=Porin OmpC from ''E. coli'', [[2j1n]] }} | {{STRUCTURE_2j1n| PDB=2j1n | SIZE=300| SCENE=Porin/Cv/1 |right|CAPTION=Porin OmpC from ''E. coli'', [[2j1n]] }} | ||
[[Porin]] or '''Outer Membrane Proteins''' '''(Omps)''' act as channels which allow passive diffusion of sugars, ions and amino acids. They are beta barrel proteins which traverse the cell membrane. In E. coli they are named according to their genes: C, F, G (OmpC, OmpF, Ompg). '''Voltage-Dependent Anion Channel (VDAC)''' is ion channel Omp found in outer mitochondrial membrane. In Pseudomonas aeruginosa the porin gene products are named OprD, OprK, OprP. The images at the left and at the right correspond to one representative | [[Porin]] or '''Outer Membrane Proteins''' '''(Omps)''' act as channels which allow passive diffusion of sugars, ions and amino acids. They are beta barrel proteins which traverse the cell membrane. In ''E. coli'' they are named according to their genes: C, F, G (OmpC, OmpF, Ompg). '''Voltage-Dependent Anion Channel (VDAC)''' is ion channel Omp found in outer mitochondrial membrane. In Pseudomonas aeruginosa the porin gene products are named OprD, OprK, OprP. The images at the left and at the right correspond to one representative porin structure, ''i.e.'' crystal structure osmoporin OmpC from ''Escherichia coli'' ([[2j1n]]). OmpC has three beta-barrels associated to form a <scene name='Porin/Cv/2'>tight trimer</scene> <ref>PMID:16949612</ref>. | ||
{{TOC limit|limit=2}} | {{TOC limit|limit=2}} | ||
| Line 11: | Line 11: | ||
[[2xe5]], [[2xe1]], [[2xe2]], [[2xe3]], [[2j1n]] – EcOmpC – ''Escherichia coli''<br /> | [[2xe5]], [[2xe1]], [[2xe2]], [[2xe3]], [[2j1n]] – EcOmpC – ''Escherichia coli''<br /> | ||
[[2j4u]] – EcOmpC+lactotransferrin fragment<br /> | [[2j4u]] – EcOmpC+lactotransferrin fragment<br /> | ||
[[3k19]], [[3k1b]], [[2zfg]], [[1omf]], [[ | [[3k19]], [[3k1b]], [[2zfg]], [[1omf]], [[1opf]] – EcOmpF<br /> | ||
[[1hxt]], [[1hxu]], [[1hxx]], [[1bt9]], [[1gfm]], [[1gfn]], [[1gfo]], [[1gfp]], [[1gfq]], [[1mpf]] – EcOmpF (mutant)<br /> | [[1hxt]], [[1hxu]], [[1hxx]], [[1bt9]], [[1gfm]], [[1gfn]], [[1gfo]], [[1gfp]], [[1gfq]], [[1mpf]] – EcOmpF (mutant)<br /> | ||
[[2zld]] – EcOmpF+colicin E3<br /> | [[2zld]] – EcOmpF+colicin E3<br /> | ||