Calcium/Calmodulin-dependent protein kinase: Difference between revisions
New page: left|200px|thumb|Crystal Structure of membrane associated Ca2+/Calmodulin dependent protein kinase, [[3mfr]] {{STRUCTURE_3mfr| PDB=3mfr | SIZE=300| SCENE= |right|CAPTI... |
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[[Image:3mfr.png|left|200px|thumb|Crystal Structure of membrane associated Ca2+/Calmodulin dependent protein kinase, [[3mfr]]]] | [[Image:3mfr.png|left|200px|thumb|Crystal Structure of membrane associated Ca2+/Calmodulin dependent protein kinase, [[3mfr]]]] | ||
{{STRUCTURE_3mfr| PDB=3mfr | SIZE=300| SCENE= |right|CAPTION=Ca2+/Calmodulin dependent protein kinase, [[3mfr]] }} | {{STRUCTURE_3mfr| PDB=3mfr | SIZE=300| SCENE= |right|CAPTION=Ca2+/Calmodulin dependent protein kinase, [[3mfr]] }} | ||
[[Ca2+/Calmodulin dependent protein kinase]] (CaMK) phosphorylates Ser and Thr. It is regulated by Ca2+/Calmodulin (CaM). It contains an N-terminal catalytic domain, regulatory domain (CBD) and association domain (ASD). CaMKI is a specialized CaM kinase while CaMKII is multifunctional kinase. CASK is a membrane associated CaMK. DAPK is a death-associated CaMK which protects cells from some programmed cell death. It contains a regulatory (RD) and autoinhibitory (AD) domains. The images at the left and at the right correspond to one representative CaMK, ''i.e.'' crystal structure of human native membrane associated Ca2+/Calmodulin dependent protein kinase ([[3mfr]]). | |||
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== 3D Structures of Ca2+/Calmodulin dependent protein kinase == | |||
=== CaMKI – specialized CaM kinase === | |||
[[3nyv]] – TgCaMK+WHI-P180 – ''Toxoplasma gondii''<br /> | |||
[[3n51]] - TgCaMK CBD +RM-1-95<br /> | |||
[[3i7b]] - TgCaMK CBD+ NM-PP1<br /> | |||
[[3i7c]] - TgCaMK CBD+ NA-PP2<br /> | |||
[[3ku2]] - TgCaMK CBD<br /> | |||
[[3khe]], [[3i79]], [[3hzt]] – TgCaMK<br /> | |||
[[3hx4]] – TgCaMK+Ca<br /> | |||
[[3dxn]] – TgCaMK kinase domain<br /> | |||
[[3mwu]] – CpCaMK CBD (mutant)+RM-1-95 – ''Cryptosporidium parvum''<br /> | |||
[[3ncg]] - CpCaMK CBD + NM-PP1<br /> | |||
[[3lij]] – CpCaMK+Ca<br /> | |||
[[3l19]], [[3igo]], [[3hko]] – CpCaMK<br /> | |||
[[2qg5]] – CpCaMK chains A, B, D<br /> | |||
[[3f3z]] – CpCaMK kinase domain+indirubin_E804<br /> | |||
[[3dfa]] - CpCaMK kinase domain<br /> | |||
[[2aao]] – CaMK chains A, B – ''Arabidopsis thaliana''<br /> | |||
[[1iq5]] – CeCaMK CBD+XlCaM – ''Xenopus laevis''<br /> | |||
[[1s6j]] – sCaMK α chain A N-terminal – soybean<br /> | |||
[[1s6i]] - sCaMK α chain A C-terminal+CaM-like domain<br /> | |||
[[1mxe]] – rCaMKI CBD+CaM – rat<br /> | |||
[[1ckk]] – rCaMK CBD chain B+XlCaM<br /> | |||
[[1a06]] – rCaMK chain A<br /> | |||
=== CASK – membrane-associated CaMK === | |||
[[3mfr]] – hCASK CBD – human<br /> | |||
[[3mfs]] – hCASK+AMPPNP<br /> | |||
[[3mft]] – hCASK+Mn<br /> | |||
[[3c0g]] – hCASK kinase domain<br /> | |||
[[3c0h]] - hCASK kinase domain+AMPPNP<br /> | |||
[[3c0i]] - hCASK kinase domain+AMP<br /> | |||
[[3mfu]] - hCASK+AMPPNP+Mn<br /> | |||
=== DAPK – death-associated CaMK === | |||
[[2x0g]] – hDAPK RD+AD+CaM<br /> | |||
[[2cke]] – hDAPK+inhibitor<br /> | |||
=== CaMKII – multifunctional CaM kinase === | |||
[[2vz6]] - hCaMKII α chains A, B+ indirubin-E804<br /> | |||
[[2zv2]] – hCaMKII+STO-609<br /> | |||
[[2wel]] - hCaMKII δ chain D+CaM<br /> | |||
[[2w2c]] - hCaMKII δ chain ASD<br /> | |||
[[2vn9]] - hCaMKII δ chains A-B<br /> | |||
[[3bhh]] - hCaMKII β chains A-D<br /> | |||
[[2v7o]] - hCaMKII γ chain A<br /> | |||
[[2ux0]] - hCaMKII γ (mutant) chains A-F<br /> | |||
[[2jam]] - hCaMKI γ+peptides<br /> | |||
[[2jc6]] - hCaMKII δ chains A,C<br /> | |||
[[1hkx]] - mCaMKII α chains A-N ASD - mouse<br /> | |||
[[3gp2]] – cCaMKII δ chain B+CaM – chicken<br /> | |||
[[3kk8]], [[3kk9]] – CeCaMKII – ''Caenorhabditis elegans''<br /> | |||
[[3kl8]] – CeCaMKII (mutant)+inhibitor<br /> | |||
[[3ksp]] – CaMKII ASD – ''Exiguobacterium sibiricum''<br /> | |||
=== CaMKIV === | |||
[[2w4o]] – hCaMKIV+inhibitor<br /> | |||
Revision as of 12:22, 2 September 2010
Ca2+/Calmodulin dependent protein kinase (CaMK) phosphorylates Ser and Thr. It is regulated by Ca2+/Calmodulin (CaM). It contains an N-terminal catalytic domain, regulatory domain (CBD) and association domain (ASD). CaMKI is a specialized CaM kinase while CaMKII is multifunctional kinase. CASK is a membrane associated CaMK. DAPK is a death-associated CaMK which protects cells from some programmed cell death. It contains a regulatory (RD) and autoinhibitory (AD) domains. The images at the left and at the right correspond to one representative CaMK, i.e. crystal structure of human native membrane associated Ca2+/Calmodulin dependent protein kinase (3mfr).
3D Structures of Ca2+/Calmodulin dependent protein kinase3D Structures of Ca2+/Calmodulin dependent protein kinase
CaMKI – specialized CaM kinaseCaMKI – specialized CaM kinase
3nyv – TgCaMK+WHI-P180 – Toxoplasma gondii
3n51 - TgCaMK CBD +RM-1-95
3i7b - TgCaMK CBD+ NM-PP1
3i7c - TgCaMK CBD+ NA-PP2
3ku2 - TgCaMK CBD
3khe, 3i79, 3hzt – TgCaMK
3hx4 – TgCaMK+Ca
3dxn – TgCaMK kinase domain
3mwu – CpCaMK CBD (mutant)+RM-1-95 – Cryptosporidium parvum
3ncg - CpCaMK CBD + NM-PP1
3lij – CpCaMK+Ca
3l19, 3igo, 3hko – CpCaMK
2qg5 – CpCaMK chains A, B, D
3f3z – CpCaMK kinase domain+indirubin_E804
3dfa - CpCaMK kinase domain
2aao – CaMK chains A, B – Arabidopsis thaliana
1iq5 – CeCaMK CBD+XlCaM – Xenopus laevis
1s6j – sCaMK α chain A N-terminal – soybean
1s6i - sCaMK α chain A C-terminal+CaM-like domain
1mxe – rCaMKI CBD+CaM – rat
1ckk – rCaMK CBD chain B+XlCaM
1a06 – rCaMK chain A
CASK – membrane-associated CaMKCASK – membrane-associated CaMK
3mfr – hCASK CBD – human
3mfs – hCASK+AMPPNP
3mft – hCASK+Mn
3c0g – hCASK kinase domain
3c0h - hCASK kinase domain+AMPPNP
3c0i - hCASK kinase domain+AMP
3mfu - hCASK+AMPPNP+Mn
DAPK – death-associated CaMKDAPK – death-associated CaMK
2x0g – hDAPK RD+AD+CaM
2cke – hDAPK+inhibitor
CaMKII – multifunctional CaM kinaseCaMKII – multifunctional CaM kinase
2vz6 - hCaMKII α chains A, B+ indirubin-E804
2zv2 – hCaMKII+STO-609
2wel - hCaMKII δ chain D+CaM
2w2c - hCaMKII δ chain ASD
2vn9 - hCaMKII δ chains A-B
3bhh - hCaMKII β chains A-D
2v7o - hCaMKII γ chain A
2ux0 - hCaMKII γ (mutant) chains A-F
2jam - hCaMKI γ+peptides
2jc6 - hCaMKII δ chains A,C
1hkx - mCaMKII α chains A-N ASD - mouse
3gp2 – cCaMKII δ chain B+CaM – chicken
3kk8, 3kk9 – CeCaMKII – Caenorhabditis elegans
3kl8 – CeCaMKII (mutant)+inhibitor
3ksp – CaMKII ASD – Exiguobacterium sibiricum
CaMKIVCaMKIV
2w4o – hCaMKIV+inhibitor