Severin: Difference between revisions
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{{STRUCTURE_3fg6| PDB=3fg6 | SCENE=Severin/Cv/4 |CAPTION=Severin, [[3fg6]] }} | {{STRUCTURE_3fg6| PDB=3fg6 | SCENE=Severin/Cv/4 |CAPTION=Severin, [[3fg6]] }} | ||
[[Severin]] is a calcium-activated protein which binds actin. The images at the top and at the right correspond to one representative Severin structure, ''i.e.'' human Severin ([[3fg6]]). It nucleates actin assembly, severes F-actin and caps actin filaments. Severin is a member of the calcium-regulated gelsolin superfamily of actin severing and capping proteins. Severin comprises 6 homologous domains (A1-A6), which share 60% identity with the 6 domains from [[Gelsolin]] (G1-G6). It is named Adseverin and Scinderin as well. The image at the right is the Severin with <scene name='Severin/Cv/5'>calcium ions</scene> (<font color='lime'><b>colored lime</b></font>). | [[Severin]] is a calcium-activated protein which binds actin. The images at the top and at the right correspond to one representative Severin structure, ''i.e.'' human Severin ([[3fg6]]). It nucleates actin assembly, severes F-actin and caps actin filaments. Severin is a member of the calcium-regulated gelsolin superfamily of actin severing and capping proteins. Whole Severin comprises 6 homologous domains (A1-A6), which share 60% identity with the 6 domains from [[Gelsolin]] (G1-G6). However, currently are crystallized only three C-terminal domains (A4-A6). It is named Adseverin and Scinderin as well. The image at the right is the Severin with <scene name='Severin/Cv/5'>calcium ions</scene> (<font color='lime'><b>colored lime</b></font>). | ||
== 3D Structures of Severin == | == 3D Structures of Severin == | ||
Revision as of 14:45, 2 August 2010
Severin is a calcium-activated protein which binds actin. The images at the top and at the right correspond to one representative Severin structure, i.e. human Severin (3fg6). It nucleates actin assembly, severes F-actin and caps actin filaments. Severin is a member of the calcium-regulated gelsolin superfamily of actin severing and capping proteins. Whole Severin comprises 6 homologous domains (A1-A6), which share 60% identity with the 6 domains from Gelsolin (G1-G6). However, currently are crystallized only three C-terminal domains (A4-A6). It is named Adseverin and Scinderin as well. The image at the right is the Severin with (colored lime).
3D Structures of Severin3D Structures of Severin
3fg6 – Adseverin C-terminal – human
1svy – Severin domain 2 – Dictyostelium discoideum
1svq - Severin domain 2 - Dictyostelium discoideum, NMR