Vinculin: Difference between revisions

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Alexander Berchansky, Jaime Prilusky, Michal Harel

Revision as of 10:48, 1 August 2010 view source Alexander Berchansky (talk \| contribs) 29,637 edits No edit summary ← Older edit		Revision as of 08:58, 2 August 2010 view source Alexander Berchansky (talk \| contribs) 29,637 edits No edit summary Newer edit →
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	{{STRUCTURE_1tr2\| PDB=1tr2 \| SIZE=300\| SCENE=Vinculin/Cv/2 \|right\|CAPTION=Human full-length Vinculin, [[1tr2]] }}		{{STRUCTURE_1tr2\| PDB=1tr2 \| SIZE=300\| SCENE=Vinculin/Cv/2 \|right\|CAPTION=Human full-length Vinculin, [[1tr2]] }}

	[[Vinculins]] (VCLs) are involved in adhesion by linking integrin molecules to the actin cytoskeleton. Its head domain (Vd1) can bind to talin or to alpha-actinin at their respective VCL Binding Sites (VBS). A splice variant of vinculin is meta-vinculin (m-VCL). The protein raver1 RNA Recognition Motif (RRM) forms a complex with VCL or m-VCL. The images at the left and at the right correspond to one representative Vinculin structure, ''i.e.'' crystal structure of human full-length Vinculin ([[1tr2]]).		[[Vinculin\|Vinculins]] (VCLs) are involved in adhesion by linking integrin molecules to the actin cytoskeleton. Its head domain (Vd1) can bind to talin or to alpha-actinin at their respective VCL Binding Sites (VBS). A splice variant of vinculin is meta-vinculin (m-VCL). The protein raver1 RNA Recognition Motif (RRM) forms a complex with VCL or m-VCL. The images at the left and at the right correspond to one representative Vinculin structure, ''i.e.'' crystal structure of human full-length Vinculin ([[1tr2]]).