Villin: Difference between revisions

New page: left|300px {{STRUCTURE_2k6n| PDB=2k6n | SCENE= |CAPTION=Human Supervillin Headpiece, 2k6n }} '''3D Structure of Villin''' <br /> The image at the top is a human...
 
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'''3D Structure of Villin''' <br />
'''3D Structure of Villin''' <br />
The image at the top is a human Human Supervillin Headpiece (3ffn)
The image at the top is a human Human Supervillin Headpiece ([[3ffn]])
 
 
== Villin ==
 
 
Villin (VIL) is an actin-binding protein.  It contains gelsolin-like domains in its N-terminal and a helical headpiece which binds actin.  Supervillin (SVIL) contains gelsolin-like domains in its C-terminal and interacts with actin.  Advillin (AVIL) is another actin-binding protein in the gelsolin family which is expressed in the peripheral sensory neurons.
 
 
== 3D Structures of Villin ==
 
=== Supervillin ===
 
 
[[2k6m]], [[2k6n]] – hSVIL headpiece– human – NMR<br />
 
 
=== Villin ===
 
 
[[3fg7]] – hVIL gelsolin domains 4-6<br />
[[1unc]] – hVIL headpiece<br />
[[2rjw]], [[2rjx]], [[2rjv]], [[2rjy]], [[1yu7]], [[1yu8]] – cVIL headpiece (mutant) – chicken<br />
[[1yu5]], [[1qqv]] - cVIL headpiece<br />
[[1vii]], [[2vik]], [[2vil]] - cVIL headpiece - NMR<br />
[[2ppz]], [[2jm0]] - VIL headpiece (mutant) – synthetic – NMR<br />
[[2f4k]], [[1wy3]], [[1wy4]], [[1yrf]], [[1yri]] - VIL fragment (mutant) – synthetic<br />
 
 
== Advillin ==
 
 
[[1und]] – hAVIL headpiece<br />

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Alexander Berchansky, Michal Harel, David Canner, Jaime Prilusky, Joel L. Sussman