Severin: Difference between revisions
New page: left|200px {{STRUCTURE_3fg6| PDB=3fg6 | SCENE= |CAPTION=Severin, 3fg6 }} '''3D Structure of Gelsolin''' <br /> == Actin Binding Protein == Severin is a calciu... |
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[[Image:3fg6.png|left|200px]] | [[Image:3fg6.png|left|200px]] | ||
{{STRUCTURE_3fg6| PDB=3fg6 | SCENE= |CAPTION=Severin, [[3fg6]] }} | {{STRUCTURE_3fg6| PDB=3fg6 | SCENE=Severin/Cv/1 |CAPTION=Severin, [[3fg6]] }} | ||
'''3D Structure of | '''3D Structure of Severin''' <br /> | ||
== Actin Binding Protein == | == Actin Binding Protein == | ||
Severin is a calcium-activated protein which binds actin. It nucleates actin assembly, severes F-actin and caps actin filaments. Severin is a member of the calcium-regulated gelsolin superfamily of actin severing and capping proteins. Severin comprises 6 homologous domains (A1-A6), which share 60% identity with the 6 domains from [[Gelsolin]] (G1-G6). It is named Adseverin and Scinderin as well. | Severin is a calcium-activated protein which binds actin. It nucleates actin assembly, severes F-actin and caps actin filaments. Severin is a member of the calcium-regulated gelsolin superfamily of actin severing and capping proteins. Severin comprises 6 homologous domains (A1-A6), which share 60% identity with the 6 domains from [[Gelsolin]] (G1-G6). It is named Adseverin and Scinderin as well. The image at the right is a <scene name='Severin/Cv/2'>octamer</scene> (each monomer is colored in different colors) of the Severin with <scene name='Severin/Cv/3'>calcium ions</scene> (<font color='lime'><b>colored lime</b></font>). | ||
== 3D Structures of Severin == | |||
[[3fg6]] – Adseverin C-terminal – human<br /> | [[3fg6]] – Adseverin C-terminal – human<br /> | ||
[[1svy]] – Severin domain 2 – ''Dictyostelium discoideum'' <br /> | [[1svy]] – Severin domain 2 – ''Dictyostelium discoideum'' <br /> | ||
[[1svq]] - Severin domain 2 - ''Dictyostelium discoideum'', NMR<br /> | [[1svq]] - Severin domain 2 - ''Dictyostelium discoideum'', NMR<br /> | ||
