Laccase: Difference between revisions
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== CotA laccase == | == CotA laccase == | ||
<applet load='1W6L' size='300' frame='true' align='right' caption='Insert caption here' /> | |||
CotA laccase belong to the multi-copper oxidase family. | CotA laccase belong to the multi-copper oxidase family. | ||
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oxidoreductase, EC 1.16.3.1). Similar to the other laccases the three dimensional struture of CotA [[1W6L]] comprises three cupredoxin domain and four copper ions organised in two copper centers: | oxidoreductase, EC 1.16.3.1). Similar to the other laccases the three dimensional struture of CotA [[1W6L]] comprises three cupredoxin domain and four copper ions organised in two copper centers: | ||
a mononuclear blue type 1 copper centre and a trinuclear centre. | a mononuclear blue type 1 copper centre and a trinuclear centre. | ||
Revision as of 18:20, 7 June 2010
CotA laccaseCotA laccase
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CotA laccase belong to the multi-copper oxidase family. The multi-copper oxidases constitute a family of enzymes whose principal members are laccase (benzenediol oxygen oxidoreductase, EC 1.10.3.2), ascorbate oxidase (L-ascorbate oxygen oxidoreductase, EC 1.10.3.3) and ceruloplasmin (Fe(II) oxygen oxidoreductase, EC 1.16.3.1). Similar to the other laccases the three dimensional struture of CotA 1W6L comprises three cupredoxin domain and four copper ions organised in two copper centers: a mononuclear blue type 1 copper centre and a trinuclear centre.
The trinuclear centre has two type 3 copper ions, that can be anti-ferromagnetically
coupled through an hydroxyl moiety in between them, and one
type 2 copper ion.‡ The mononuclear copper is able to accept an
electron froma variety of phenolic substrates and then transmits
it to the trinuclear centre.