2bpi: Difference between revisions
No edit summary |
No edit summary |
||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
2BPI is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]] with FE as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ | 2BPI is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]] with FE as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BPI OCA]]. | ||
==Reference== | ==Reference== | ||
| Line 14: | Line 14: | ||
[[Category: Plasmodium falciparum]] | [[Category: Plasmodium falciparum]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Superoxide dismutase]] | |||
[[Category: Boucher, I.W.]] | [[Category: Boucher, I.W.]] | ||
[[Category: Brannigan, J.A.]] | [[Category: Brannigan, J.A.]] | ||
| Line 23: | Line 24: | ||
[[Category: oxidoreductase]] | [[Category: oxidoreductase]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 10:40:50 2007'' | ||
Revision as of 11:36, 30 October 2007
|
STUCTURE OF IRON DEPENDENT SUPEROXIDE DISMUTASE FROM P. FALCIPARUM.
OverviewOverview
BACKGROUND: Superoxide dismutases (SODs) are important enzymes in defence, against oxidative stress. In Plasmodium falciparum, they may be expected, to have special significance since part of the parasite life cycle is, spent in red blood cells where the formation of reactive oxygen species is, likely to be promoted by the products of haemoglobin breakdown. Thus, inhibitors of P. falciparum SODs have potential as anti-malarial, compounds. As a step towards their development we have determined the, crystal structure of the parasite's cytosolic iron superoxide dismutase., RESULTS: The cytosolic iron superoxide dismutase from P. falciparum, (PfFeSOD) has been overexpressed in E. coli in a catalytically active, form. Its crystal structure has been solved by molecular replacement and, refined ... [(full description)]
About this StructureAbout this Structure
2BPI is a [Single protein] structure of sequence from [Plasmodium falciparum] with FE as [ligand]. Active as [Superoxide dismutase], with EC number [1.15.1.1]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
The crystal structure of superoxide dismutase from Plasmodium falciparum., Boucher IW, Brzozowski AM, Brannigan JA, Schnick C, Smith DJ, Kyes SA, Wilkinson AJ, BMC Struct Biol. 2006 Oct 4;6:20. PMID:17020617
Page seeded by OCA on Tue Oct 30 10:40:50 2007