Triose Phosphate Isomerase: Difference between revisions
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'''Role in Alzheimer's Disease''': Recent discoveries in Alzheimer Disease research has indicated that amyloid beta-peptide induced nitro-oxidative damage promotes the nitrotyrosination of the glycolytic enzyme triosephosphate isomerase in human neuroblastoma cells.<ref>PMID:19251756</ref> nitro-triosephosphate isomerase was found to be present in brain slides from double transgenic mice overexpressing human amyloid precursor protein as well as in Alzheimer's disease patients. Specifically, the nitrotyrosination occurs on <scene name='Triose_Phosphate_Isomerase/Two_tyrosines_shaded/2'>Tyr164 and Tyr208</scene> , which are located in close proximity to the catalytic center, and this modification correlates with a reduced isomerase activity. Additionally, according to work done by Francesc Guix and colleagues, nitro-triosphosphate isomerase contributed to the formation of large beta-sheet aggregates ''in vitro'' and ''in vivo''. | '''Role in Alzheimer's Disease''': Recent discoveries in Alzheimer Disease research has indicated that amyloid beta-peptide induced nitro-oxidative damage promotes the nitrotyrosination of the glycolytic enzyme triosephosphate isomerase in human neuroblastoma cells.<ref>PMID:19251756</ref> nitro-triosephosphate isomerase was found to be present in brain slides from double transgenic mice overexpressing human amyloid precursor protein as well as in Alzheimer's disease patients. Specifically, the nitrotyrosination occurs on <scene name='Triose_Phosphate_Isomerase/Two_tyrosines_shaded/2'>Tyr164 and Tyr208</scene> , which are located in close proximity to the catalytic center, and this modification correlates with a reduced isomerase activity. Additionally, according to work done by Francesc Guix and colleagues, nitro-triosphosphate isomerase contributed to the formation of large beta-sheet aggregates ''in vitro'' and ''in vivo''. | ||
==Evolutionary Conservation== | ==Evolutionary Conservation== | ||
{{STRUCTURE_2ypi| PDB=2ypi | SCENE=Triose_Phosphate_Isomerase/Conserved/1}} | {{STRUCTURE_2ypi| PDB=2ypi | SCENE=Triose_Phosphate_Isomerase/Conserved/1}} | ||