Molecular Playground/ERMan1: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

@@ Line 1: / Line 1: @@
 ==This is a placeholder==
-Alpha-mannosidases I(ERMan1) is a human protein that reside in the endoplasmic reticulum(ER) lumen. ERMan1 is part of the class 1 glycosylhydrolase family 47 group of proteins and sports a Tim-barrel fold. In the ER N-linked glycans are used as indicators of how well a client protein is folded. ERMan1 functions by slowly trimming N-linked glycans, giving the protein at hand a defined window of time before the client protein can be targeted for degradation by other ER proteins.
+Alpha-mannosidases I(ERMan1) is a human protein that reside in the endoplasmic reticulum(ER). ERMan1 is part of the class 1 glycosylhydrolase family 47 group of proteins and sports a Tim-barrel fold. In N-linked glycans are common covalent modifiers in the ER that aid in protein folding and trafficking. ERMan1 trims N-linked glycans to make the client protein targeted for degradation. The slow acting kinetics of ERMan1 has been proposed to give at hand a defined window of time before the client protein can be targeted for degradation by other ER proteins.
@@ Line 11: / Line 11: @@
 [http://proteopedia.org/wiki/index.php/CBI_Molecules]
+[http://proteopedia.org/wiki/index.php/1x9d]