3m35: Difference between revisions

Revision as of 09:56, 21 April 2010

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File:3m35.jpg

Template:STRUCTURE 3m35

Trypsin in complex with the inhibitor 1-[3-(aminomethyl)phenyl]-N-[3-fluoro-2'-(methylsulfonyl)biphenyl-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423)Trypsin in complex with the inhibitor 1-[3-(aminomethyl)phenyl]-N-[3-fluoro-2'-(methylsulfonyl)biphenyl-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423)

Template:ABSTRACT PUBMED 14640539

About this StructureAbout this Structure

3M35 is a 1 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA.

ReferenceReference

^{[xtra 1]}

↑ Pruitt JR, Pinto DJ, Galemmo RA Jr, Alexander RS, Rossi KA, Wells BL, Drummond S, Bostrom LL, Burdick D, Bruckner R, Chen H, Smallwood A, Wong PC, Wright MR, Bai S, Luettgen JM, Knabb RM, Lam PY, Wexler RR. Discovery of 1-(2-aminomethylphenyl)-3-trifluoromethyl-N- [3-fluoro-2'-(aminosulfonyl)[1,1'-biphenyl)]-4-yl]-1H-pyrazole-5-carboxyam ide (DPC602), a potent, selective, and orally bioavailable factor Xa inhibitor(1). J Med Chem. 2003 Dec 4;46(25):5298-315. PMID:14640539 doi:10.1021/jm030212h

Page seeded by OCA on Wed Apr 21 09:56:40 2010

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Pruitt JR, Pinto DJ, Galemmo RA Jr, Alexander RS, Rossi KA, Wells BL, Drummond S, Bostrom LL, Burdick D, Bruckner R, Chen H, Smallwood A, Wong PC, Wright MR, Bai S, Luettgen JM, Knabb RM, Lam PY, Wexler RR. Discovery of 1-(2-aminomethylphenyl)-3-trifluoromethyl-N- [3-fluoro-2'-(aminosulfonyl)[1,1'-biphenyl)]-4-yl]-1H-pyrazole-5-carboxyam ide (DPC602), a potent, selective, and orally bioavailable factor Xa inhibitor(1). J Med Chem. 2003 Dec 4;46(25):5298-315. PMID:14640539 doi:10.1021/jm030212h

[xtra 1]

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-'''Unreleased structure'''
+{{Seed}}
+[[Image:3m35.jpg|left|200px]]
-The entry 3m35 is ON HOLD
+<!--
+The line below this paragraph, containing "STRUCTURE_3m35", creates the "Structure Box" on the page.
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+or leave the SCENE parameter empty for the default display.
+-->
+{{STRUCTURE_3m35|  PDB=3m35  |  SCENE=  }}
-Authors: Alexander, R.S.
+===Trypsin in complex with the inhibitor 1-[3-(aminomethyl)phenyl]-N-[3-fluoro-2'-(methylsulfonyl)biphenyl-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423)===
-Description: Trypsin in complex with the inhibitor 1-(3-(aminomethyl)phenyl)-n-(3-fluoro-2'-(methylsulfonyl)-4-biphenylyl)-3-(trifluoromethyl)-1h-pyrazole-5-carboxamide (DPC423)
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 24 08:38:09 2010''
+<!--
+The line below this paragraph, {{ABSTRACT_PUBMED_14640539}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 14640539 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_14640539}}
+==About this Structure==
+M35 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M35 OCA].
+==Reference==
+<ref group="xtra">PMID:14640539</ref><references group="xtra"/>
+[[Category: Bos taurus]]
+[[Category: Trypsin]]
+[[Category: Alexander, R S.]]
+[[Category: Digestion]]
+[[Category: Disulfide bond]]
+[[Category: Hydrolase]]
+[[Category: Metal-binding]]
+[[Category: Pancrea]]
+[[Category: Protease]]
+[[Category: Secreted]]
+[[Category: Serine protease]]
+[[Category: Zymogen]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 21 09:56:40 2010''