Avian Influenza Neuraminidase, Tamiflu and Relenza: Difference between revisions
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Two common mutations that confer resistance to Tamiflu did not confer resistance to Relenza<ref name="collins2008" />. At right is Relenza binding to the H274Y mutant of N1. (Wild type amino acids within 3 Å of Relenza are shown as thin sticks. <scene name='User:Eric_Martz/Molecular_Playground/Authoring/3ckz_relenza_tyr274/7'>Zoom out and back in</scene>.) This suggests that it would be prudent to stockpile Relenza in addition to Tamiflu, and that combination therapy might be the most effective weapon against a new pandemic, prior to development and deployment of a vaccine. | Two common mutations that confer resistance to Tamiflu did not confer resistance to Relenza<ref name="collins2008" />. At right is Relenza binding to the H274Y mutant of N1. (Wild type amino acids within 3 Å of Relenza are shown as thin sticks. <scene name='User:Eric_Martz/Molecular_Playground/Authoring/3ckz_relenza_tyr274/7'>Zoom out and back in</scene>.) This suggests that it would be prudent to stockpile Relenza in addition to Tamiflu, and that combination therapy might be the most effective weapon against a new pandemic, prior to development and deployment of a vaccine. | ||
[[User:David S. Goodsell]]'s Molecule of the Month article on Influenza Neuraminidase (see link [[#See Also|below]]) includes an instructive [http://www.pdb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb113_jmol.html visualization of an alignment] in Jmol showing wild-type and mutant N1 with sialic acid or Tamiflu (oseltamivir) bound. | |||
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